Sequence reactivation in the hippocampus is impaired in aged rats
Sequence reactivation in the hippocampus is impaired in aged rats
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DOI：
10.1523/jneurosci.1265-08.2008
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发表时间：
2008-07-30
影响因子：
5.3
通讯作者：
Barnes, Carol A.
中科院分区：
文献类型：
--
作者：
Gerrard, Jason L.;Burke, Sara N.;Barnes, Carol A.
海马体被认为是通过在大脑不积极处理新输入时重新激活行为经验的痕迹来协调记忆巩固。事实上，在慢波睡眠期间，年轻和老年大鼠的CA1锥体细胞群活动相关性的模式被重新激活。除了相关的活动模式，重复的轨道运行也创造了一个重复序列的锥体细胞活动。本研究比较了CA1序列活动模式重放在年轻和老年动物在休息期间后的行为。虽然年轻大鼠表现出显着的序列重新激活，但老年动物的序列重新激活明显受损。当将所有动物的空间记忆分数与序列再激活的程度进行比较时，存在显著的相关性。时间模式的弱重放具有行为后果的新发现，加强了重新激活过程是记忆巩固不可或缺的想法。
The hippocampus is thought to coordinate memory consolidation by reactivating traces from behavioral experience when the brain is not actively processing new input. In fact, during slow-wave sleep, the patterns of CA1 pyramidal cell ensemble activity correlations are reactivated in both young and aged rats. In addition to correlated activity patterns, repetitive track running also creates a recurring sequence of pyramidal cell activity. The present study compared CA1 sequence activity pattern replay in young and old animals during rest periods after behavior. Whereas the young rats exhibited significant sequence reactivation, it was markedly impaired in the aged animals. When the spatial memory scores of all animals were compared with the degree of sequence reactivation, there was a significant correlation. The novel finding that weak replay of temporal patterns has behavioral consequences, strengthens the idea that reactivation processes are integral to memory consolidation.