Estrogen receptor-β inhibits skeletal growth and has the capacity to mediate growth plate fusion in female mice
Estrogen receptor-β inhibits skeletal growth and has the capacity to mediate growth plate fusion in female mice
复制标题
DOI：
10.1359/jbmr.0301203
复制
发表时间：
2004-01-01
影响因子：
6.2
通讯作者：
Ohlsson, C
中科院分区：
文献类型：
--
作者：
Chagin, AS;Lindberg, MK;Ohlsson, C
为了确定ERbeta在纵向骨生长调控中的长期作用，我们对雌性ERbeta（-/-）、ERalpha（-/-）和ERalpha(-/-) β(-/-)小鼠的阑尾骨和轴向骨生长进行了跟踪和比较。我们的研究结果表明ERbeta抑制附肢和轴向骨骼生长，并具有诱导生长板融合的能力。
To determine the long-term role of ERbeta in the regulation of longitudinal bone growth, appendicular and axial skeletal growth was followed and compared in female ERbeta(-/-), ERalpha(-/-), and ERalpha(-/-)beta(-/-) mice. Our results show that ERbeta inhibits appendicular and axial skeletal growth and has the capacity to induce fusion of the growth plates.