Light-Responsive Nanoparticles for Highly Efficient Cytoplasmic Delivery of Anticancer Agents
Light-Responsive Nanoparticles for Highly Efficient Cytoplasmic Delivery of Anticancer Agents
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用于高效细胞质递送抗癌药物的光响应纳米颗粒
DOI：
10.1021/acsnano.7b05214
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发表时间：
2017
期刊：
影响因子：
17.1
通讯作者：
Chen Huabing
中科院分区：
文献类型：
--
作者：
Wang Yangyun;Deng Yibin;Luo Huanhuan;Zhu Aijun;Ke Hengte;Yang Hong;Chen Huabing
刺激响应纳米结构已经显示出抗癌化合物的细胞内递送的巨大前景。一个关键的挑战仍然是在探索刺激响应纳米粒子的快速细胞质输送。在此，近红外（NIR）光响应纳米粒子的合理设计，以产生高效的细胞质输送抗癌药物的协同热化疗。硒插入共聚物（I/D-Se-NPs）的载药聚合物纳米颗粒在NIR光暴露时通过活性氧（ROS）介导的硒氧化在几分钟内迅速解离，并且在如此短的照射后I/D-Se-NPs的这种不可逆解离促进了连续的药物释放。此外，I/D-Se-NPs通过ROS触发的溶酶体破坏促进细胞质药物移位，从而导致高度优选的分布到细胞核，甚至在照射后5分钟，这进一步与光触发的热疗结合，用于实现协同的肿瘤消融而没有肿瘤再生长。
Stimuli-responsive nanostructures have shown great promise for intracellular delivery of anticancer compounds. A critical challenge remains in the exploration of stimuli-responsive nanoparticles for fast cytoplasmic delivery. Herein, near-infrared (NIR) light-responsive nanoparticles were rationally designed to generate highly efficient cytoplasmic delivery of anticancer agents for synergistic thermo-chemotherapy. The drug-loaded polymeric nanoparticles of selenium-inserted copolymer (I/D-Se-NPs) were rapidly dissociated in several minutes through reactive oxygen species (ROS)-mediated selenium oxidation upon NIR light exposure, and this irreversible dissociation of I/D-Se-NPs upon such a short irradiation promoted continuous drug release. Moreover, I/D-Se-NPs facilitated cytoplasmic drug translocation through ROS-triggered lysosomal disruption and thus resulted in highly preferable distribution to the nucleus even in 5 min postirradiation, which was further integrated with light-triggered hyperthermia for achieving synergistic tumor ablation without tumor regrowth.