Development and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for curcumin transdermal delivery: an anti-inflammatory exposure
Development and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for curcumin transdermal delivery: an anti-inflammatory exposure
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DOI：
10.1080/03639045.2019.1593440
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发表时间：
2019-04-14
影响因子：
3.4
通讯作者：
Raish, Mohammad
中科院分区：
文献类型：
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作者：
Altamimi, Mohammad A.;Kaz, Mohsin;Raish, Mohammad
本研究的目的是开发一种新型的脂质自纳米乳化给药系统（SNEDDS）作为姜黄素经皮给药载体。以黑籽油、中链单甘油酯、双甘油酯和表面活性剂为载体，制备了姜黄素载体SNEDDS。对它们的形成自发性、形态、液滴大小和载药量进行了评价。采用含两种SNEDDS制剂的凝胶制剂对卡拉胶致足跖水肿进行抗炎作用评价。结果表明，微滴粒径可达71 nm。SNEDDS-F6的载药量最高，约为45 mg/g。在体内研究中，与阳性对照相比，SNEDDS-F6表现出显著的抗炎活性，足跖水肿减少80%。所制备的SNEDDS包埋效率高，透皮渗透能力好，是姜黄素有效透皮给药的合适人选。
The purpose of this work is to develop novel lipid-based self-nanoemulsifying drug delivery systems (SNEDDS) as carriers for transdermal delivery of curcumin. SNEDDS containing black seed oil, medium chain mono- and diglycerides and surfactants, were prepared as curcumin delivery vehicles. Their formation spontaneity, morphology, droplet size, and drug loading were evaluated. Gel preparation containing two of the SNEDDS formulations were used in the carrageenan induced paw edema to evaluate the anti-inflammatory effect. Results showed droplet size as low as 71 nm. The highest drug loading was observed with SNEDDS-F6 of similar to 45 mg/g. In in-vivo investigation, SNEDDS-F6 exhibited significant anti-inflammatory activities in terms of 80% reduction in paw edema when compared with positive control. The prepared SNEDDS with the elevated entrapment efficiency, good transdermal penetration ability could be a suitable candidate for effective transdermal curcumin skin delivery.