The Human Mycobiome and its Impact on Health and Disease
The Human Mycobiome and its Impact on Health and Disease
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DOI：
10.1007/s12281-013-0162-x
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发表时间：
2013-12-01
影响因子：
1.4
通讯作者：
Mukherjee, Pranab K.
中科院分区：
文献类型：
--
作者：
Ghannoum, Mahmoud A.;Mukherjee, Pranab K.
直到最近，人类微生物组一直是细菌群落的同义词。幸运的是，最近的研究表明，人体微生物组是复杂的，由细菌，真菌和病毒组成。表征健康中的真菌群落“真菌群落”（涉及口腔，皮肤和胃肠道身体部位）为定义该群落在疾病中经历的变化铺平了道路。虽然研究疾病中真菌生物群的研究数量很少，但这些研究的结果令人兴奋，并开始表明真菌除了作为正常植物群或直接病原体的作用外，还可能加重特定患者人群的疾病症状（例如，溃疡性结肠炎患者的炎症）。这些意想不到的发现为旨在阐明真菌群落及其与其他微生物群落在免疫功能低下疾病中的作用的研究提供了动力。为这些研究工作提供资金是必要的。
Until recently, the human microbiome was synonymous with the bacterial community. Fortunately, recent studies have shown that the human microbiome is complex and composed of bacteria, fungi and viruses. Characterizing the fungal community "mycobiome" in health (involving oral cavity, skin, and gastrointestinal tract body sites) is paving the way to defining the changes that this community undergoes in disease. Although the number of studies investigating the mycobiome in disease is small, findings from these investigations are exciting and beginning to show that fungi, apart from their role as normal flora or direct pathogens, may aggravate disease symptoms in specific patient populations (e.g., inflammation in patients with ulcerative colitis). Such unexpected findings provide impetus for the conduct of research aimed at elucidating the role of the fungal community, and its interactions with other microbial communities, in immunocompromised diseases. Funding of these research efforts is warranted.