Runx2 in normal tissues and cancer cells: A developing story
Runx2 in normal tissues and cancer cells: A developing story
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DOI：
10.1016/j.bcmd.2010.05.007
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发表时间：
2010-08-15
影响因子：
2.3
通讯作者：
Cameron, Ewan R.
中科院分区：
文献类型：
--
作者：
Blyth, Karen;Vaillant, Francois;Cameron, Ewan R.
Runx 转录因子对于哺乳动物发育至关重要，尤其是在造血和成骨谱系中。 Runx1 及其结合伙伴 CBF beta 经常成为急性白血病的靶标，但越来越多的证据表明，所有三个 Runx 基因可能在更广泛的癌症中发挥作用，无论是作为肿瘤促进剂还是肿瘤抑制因子。虽然 Runx2 因其作为骨骼发育的主要调节因子而闻名，但我们在此讨论其表达模式和超出该谱系的假定功能。此外，我们回顾了 RUNX2 促进造血谱系以及晚期乳腺癌和前列腺癌肿瘤发展的证据。 (C) 2010 Elsevier Inc. 保留所有权利。
The Runx transcription factors are essential for mammalian development, most notably in the haematopoietic and osteogenic lineages. Runx1 and its binding partner, CBF beta,, are frequently targeted in acute leukaemia but evidence is accumulating that all three Runx genes may have a role to play in a wider range of cancers, either as tumour promoters or tumour suppressors. Whilst Runx2 is renowned for its role as a master regulator of bone development we discuss here its expression pattern and putative functions beyond this lineage. Furthermore, we review the evidence that RUNX2 promotes neoplastic development in haematopoietic lineages and in advanced mammary and prostate cancer. (C) 2010 Elsevier Inc. All rights reserved.