Medical Applications of Porous Biomaterials: Features of Porosity and Tissue-Specific Implications for Biocompatibility.
Medical Applications of Porous Biomaterials: Features of Porosity and Tissue-Specific Implications for Biocompatibility.
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多孔生物材料的医学应用：孔隙度特征和生物相容性的组织特异性影响。
DOI：
10.1002/adhm.202102087
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发表时间：
2022-05
影响因子：
10
通讯作者：
中科院分区：
文献类型：
--
作者：
多孔性是植入物和组织支架中常用的重要材料特征。物质空洞的存在允许细胞浸润、机械顺应和药物向外扩散。各种研究已经证实，孔隙度确实促进了有利的组织反应，包括在异物反应（FBR）过程中最小的纤维包封。然而，增加的生物膜形成和钙化也被描述为由于生物材料孔隙。此外，宿主反应（如FBR、感染、钙化和血栓形成）的相关性取决于组织位置和特定的组织微环境。在这篇综述中，我们讨论了多孔材料的特征，以及多孔性在医疗器械中的含义。还讨论了制造多孔材料的常用方法，以及用于调整孔隙特征的参数。对多孔生物材料的反应也进行了回顾，包括FBR的各个阶段，血液相容性，生物膜形成和钙化。最后，这些宿主反应被认为是在组织的特定部位，包括皮下、骨骼、心血管系统、大脑、眼睛和女性生殖道。我们强调孔隙度对人体各种组织的影响，并强调在工程生物材料时需要考虑组织背景。多孔性是生物材料的一个重要特征，它使生物材料具有功能性和细胞整合能力，通常被描述为具有更大的生物相容性的反应。在这篇综述中，我们讨论了用于制造多孔材料的方法，孔隙率和比孔径对各种宿主反应的影响，以及在组织特异性微环境中发生的反应。
Porosity is an important material feature commonly employed in implants and tissue scaffolds. The presence of material voids permits the infiltration of cells, mechanical compliance, and outward diffusion of pharmaceutical agents. Various studies have confirmed that porosity indeed promotes favorable tissue responses, including minimal fibrous encapsulation during the foreign body reaction (FBR). However, increased biofilm formation and calcification is also described to arise due to biomaterial porosity. Additionally, the relevance of host responses like the FBR, infection, calcification, and thrombosis are dependent on tissue location and specific tissue microenvironment. In this review, we discuss the features of porous materials, and the implications of porosity in the context of medical devices. Common methods to create porous materials are also discussed, as well as the parameters which have been used to tune pore features. Responses towards porous biomaterials are also reviewed, including the various stages of the FBR, hemocompatibility, biofilm formation, and calcification. Finally, these host responses are considered in tissue specific locations including the subcutis, bone, cardiovascular system, brain, eye, and female reproductive tract. We highlight the effects of porosity across the various tissues of the body and emphasize the need to consider the tissue context when engineering biomaterials. Porosity is an important biomaterial feature which enables biomaterial functionality and the capacity for cell integration, which is commonly characterized as a response with greater biocompatibility. In this review, we discuss methods used for fabricating porous materials, the effect porosity and specific pore size has on various host responses, and the responses which occur in tissue-specific microenvironments.
子宫基质金属蛋白酶-9 的调节和 microRNA 的作用。
影响因子：
2.7
作者：
Nothnick WB
通讯作者：
Nothnick WB