“Fabrication of arbitrarily shaped carbonate apatite foam based on the interlocking process of dicalcium hydrogen phosphate dihydrate”
“Fabrication of arbitrarily shaped carbonate apatite foam based on the interlocking process of dicalcium hydrogen phosphate dihydrate”
复制标题
“基于二水磷酸氢二钙的联锁过程制备任意形状的碳酸盐磷灰石泡沫”
DOI：
10.1007/s10856-017-5937-0
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Ishikawa Kunio
中科院分区：
文献类型：
--
作者：
Sugiura Yuki;Tsuru Kanji;Ishikawa Kunio
碳酸盐磷灰石(CO3Ap)泡沫具有相互连通的多孔结构，是一种非常有吸引力的骨替代支架。本研究以α-磷酸三钙(α-TcP)泡沫颗粒为原料，通过先用酸性磷酸钙溶液处理，再用NaHCO3水热处理两步法制备了任意形状的CO3Ap泡沫。酸性磷酸钙溶液的处理是制备任意形状的CO3Ap泡沫的关键，它使二水磷酸氢钙(DCPD)晶体在α-TCPP泡沫颗粒上形成。生成的DCPD晶体使α-TcP颗粒彼此互锁，形成α-TcP/DCPD泡沫。含有DCPD晶体的联锁结构可以在NaHCO3的水热处理中存活下来。以α-TcP/DCPD泡沫为原料，在大量NaHCO3存在下，于2 0 0 °C水热处理2 4h，制得了任意形状的CO3Ap泡沫。
Carbonate apatite (CO3Ap) foam with an interconnected porous structure is highly attractive as a scaffold for bone replacement. In this study, arbitrarily shaped CO3Ap foam was formed from α-tricalcium phosphate (α-TCP) foam granules via a two-step process involving treatment with acidic calcium phosphate solution followed by hydrothermal treatment with NaHCO3. The treatment with acidic calcium phosphate solution, which is key to fabricating arbitrarily shaped CO3Ap foam, enables dicalcium hydrogen phosphate dihydrate (DCPD) crystals to form on the α-TCP foam granules. The generated DCPD crystals cause the α-TCP granules to interlock with each other, inducing an α-TCP/DCPD foam. The interlocking structure containing DCPD crystals can survive hydrothermal treatment with NaHCO3. The arbitrarily shaped CO3Ap foam was fabricated from the α-TCP/DCPD foam via hydrothermal treatment at 200 °C for 24 h in the presence of a large amount of NaHCO3.