Exposure-response relationship of the association between aircraft noise and the risk of hypertension
Exposure-response relationship of the association between aircraft noise and the risk of hypertension
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DOI：
10.4103/1463-1741.53363
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发表时间：
2009-07-01
期刊：
影响因子：
0.7
通讯作者：
van Kamp, Irene
中科院分区：
文献类型：
--
作者：
Babisch, Wolfgang;van Kamp, Irene
噪音是一种影响自主神经系统和内分泌系统的压力源。在慢性噪声应激条件下，心血管系统可能受到不利影响。已经对成人和儿童进行了关于飞机噪声与心血管影响之间关系的流行病学噪声研究，重点关注平均血压、高血压和缺血性心脏病作为心血管终点。虽然有证据表明，道路交通噪音会增加缺血性心脏病（包括心肌梗死）的风险，但很少有证据表明这种关联与飞机噪音有关。这部分是由于缺乏大规模的临床研究。然而，有足够的定性证据表明，飞机噪音会增加成年人患高血压的风险。关于飞机噪音和儿童血压的关系，结果仍然不一致。根据专家在这一领域的全面知识，为世卫组织“飞机噪音与健康”工作组评估了现有文献。考虑到对疾病负担计算进行定量风险评估的需要，我们尝试在荟萃分析的基础上得出暴露-反应关系。这种联系必须被视为初步的，因为在研究之间的暴露评估和结果的方法上存在差异，因此涉及到汇集研究的局限性。需要更多的研究来建立更好的风险估计。
Noise is a stressor that affects the autonomic nervous system and the endocrine system. Under conditions of chronic noise stress the cardiovascular system may adversely be affected. Epidemiological noise studies regarding the relationship between aircraft noise and cardiovascular effects have been carried out on adults and on children focussing on mean blood pressure, hypertension and ischemic heart diseases as cardiovascular endpoints. While there is evidence that road traffic noise increases the risk of ischemic heart disease, including myocardial infarction, there is less such evidence for such an association with aircraft noise. This is partly due to the fact that large scale clinical studies are missing. There is sufficient qualitative evidence, however, that aircraft noise increases the risk of hypertension in adults. Regarding aircraft noise and children's blood pressure the results are still inconsistent. The available literature was evaluated for the WHO working group on "Aircraft Noise and Health" based on the experts' comprehensive knowledge in this field. With respect to the needs of a quantitative risk assessment for burden of disease calculations an attempt was made to derive an exposure-response relationship based on a meta-analysis. This association must be viewed as preliminary due to limitations which are concerned with the pooling of studies due to methodological differences in the assessment of exposure and outcome between studies. More studies are needed to establish better estimates of the risk.