Effect of erionite on the pleural mesothelium of the Fischer 344 rat
Effect of erionite on the pleural mesothelium of the Fischer 344 rat
复制标题
DOI：
10.1378/chest.111.5.1375
复制
发表时间：
1997-05-01
期刊：
影响因子：
9.6
通讯作者：
Roggli, VL
中科院分区：
文献类型：
--
作者：
Fraire, AE;Greenberg, SD;Roggli, VL
目的：本研究旨在评估毛沸石的纤维化和致癌潜力（纤维沸石）在Fischer 344大鼠（n=24）的胸膜间皮上的作用。本研究旨在通过三名独立的观察者以一定的时间间隔检查大鼠胸膜间皮膜的变化，时间间隔为接种后1至480天，使用来自Pine Valley，内华达州（USA）地区的毛沸石，毛沸石纤维的平均长度为2.29 μ m，平均宽度为0.48 μ m，只有大多数（2/3）或少数（3/3）的显微镜观察才能被接受。21/24只大鼠的胸膜和肺组织可用于检查，6/21只大鼠发生纤维化、慢性炎症和异物反应，21只大鼠中，分别有9只和3只发生间皮增生和发育不良。一个单一的间皮瘤被确定为在434天的大鼠，有严重的结节性胸膜lesions.Conclusions：本文报道的研究结果证实了强大的纤维化的潜力毛蕊石，但在valvalvial与以前的研究报告更高的收益率间皮瘤。本研究中间皮瘤产量低的原因尚不清楚，但可能与研究设计、用于组织病理学诊断的严格标准和/或毛沸石理化性质的可能差异有关，与其地理分布有关，大多数先前的动物研究使用来自罗马，俄勒冈州（美国）地区的毛沸石。
Objective: This study sought to assess the fibrogenic and carcinogenic potential of erionite (a fibrous zeolite) on the pleural mesothelium of the Fischer 344 rat (n=24).Design: The study was designed to examine rat pleural mesothelial changes by three independent observers at timed intervals, ranging from 1 to 480 days postinoculation using erionite fr om the Pine Valley, Nevada (USA) area, The mean length and width of the erionite fibers were 2.29 and 0.48 mu m, respectively, Only microscopic observations made by majority (2/3) or unanimity (3/3) were accepted for final diagnosis.Results: Pleural and lung tissue were available for examination in 21 of the 24 rats, Fibrosis, chronic inflammation, and foreign body reaction occurred in 6 of 21 rats, Mesothelial hyperplasia and dysplasia occurred in 9 and 3 of the 21 rats, respectively. A single mesothelioma was identified at 434 days in a rat that had gross nodular pleural lesions.Conclusions: The findings reported herein confirm the strong fibrogenic potential of erionite but are at valiance with previous studies reporting much higher yields of mesothelioma. The reasons for the low yield of mesothelioma in this study are not known, but may be related to the study design, the strict criteria used for histopathologic diagnosis, and/or possible differences in erionite physicochemical properties, associated with its geographic distribution, most previous animal studies having used erionite from the Rome, Oregon (USA) area.