Temporary HMCES-DNA cross-link prevents permanent DNA damage.
Temporary HMCES-DNA cross-link prevents permanent DNA damage.
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临时 HMCES-DNA 交联可防止永久性 DNA 损伤。
DOI：
10.1016/j.celrep.2023.113594
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发表时间：
2024
期刊：
影响因子：
8.8
通讯作者：
Smogorzewska,Agata
中科院分区：
文献类型：
--
作者：
Ruiz,PenelopeD;Smogorzewska,Agata
HMCES是一种最近发现的古老蛋白质，它共价连接到受损的单链DNA上，并保护它免受核酸酶的侵害。Rua-Fernandez及其同事现在表明，HMCES催化其自身的再循环，允许正常生长和非诱变性DNA修复。
HMCES, a recently discovered but ancient protein, covalently attaches to damaged single-stranded DNA and shields it from nucleases. Rua-Fernandez and colleagues now show that HMCES catalyzes its own recycling, permitting normal growth and non-mutagenic DNA repair.1