Polymorphisms of MTHFR C677T and A1298C Association With Oral Carcinoma Risk: A Meta-Analysis
Polymorphisms of MTHFR C677T and A1298C Association With Oral Carcinoma Risk: A Meta-Analysis
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DOI：
10.3109/07357907.2012.681820
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发表时间：
2012-07-01
影响因子：
2.4
通讯作者：
Tan, Yinghui
中科院分区：
文献类型：
--
作者：
Zhuo, Xianlu;Ling, Junjun;Tan, Yinghui
关于MTHFR多态性与口腔癌风险相关性的研究尚未得出结论性结果。因此，进行了荟萃分析。结果表明，没有观察到C677T多态性与口腔癌的整体数据。在饮酒状态的亚组分析中，纯合子TT等位基因在重度饮酒者中表现出较高的口腔癌易感性。在A1298C多态性中，CC等位基因可能对口腔癌有预防作用。总的来说，结果表明，MTHFR 677TT多态性可能是一个低渗透的危险因素，口腔癌只有在大量饮酒者。而1298CC等位基因可能对口腔癌有预防作用。
Investigations regarding association of MTHFR polymorphisms with oral carcinoma risk have yielded inconclusive results. Thus, meta-analyses were performed. Results showed that no associations of C677T polymorphisms with oral carcinoma were observed for the overall data. In subgroup analyses by drinking status, homozygous TT alleles exhibited elevated oral cancer susceptibility in heavy drinkers. For A1298C polymorphism, CC alleles presented a possible preventive role for oral cancer. Collectively, results suggest that MTHFR 677TT polymorphism might be a low-penetrant risk factor for oral carcinoma only in heavy drinkers. Conversely, 1298CC alleles might play a preventive role for oral cancer.