The interaction of misonidazole with radiation, chemotherapeutic agents, or heat: a preliminary report.
The interaction of misonidazole with radiation, chemotherapeutic agents, or heat: a preliminary report.
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米索硝唑与辐射、化疗药物或热的相互作用：初步报告。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
C. Williamson
中科院分区：
文献类型：
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作者：
I. Stratford;G. Adams;M. Horsman;S. Kandaiya;S. Rajaratnam;E. Smith;C. Williamson
在37 ℃下暴露于米索硝唑的缺氧细胞的存活显示出初始滞后期，之后存活随时间呈指数下降。与米索硝唑一起孵育的时间相当于存活曲线上的滞后期的时间的低分化细胞在随后给予X射线照射时显示出增加的敏感性。这与以前发表的意见一致。此外，预孵育缺氧细胞与米索硝唑ata 37摄氏度也使细胞更敏感的后续治疗热或美法仑，氮芥和顺式铂（II）。预孵育必须在缺氧条件下进行，细胞才能对第二次损伤敏感;即使在空气中预孵育5 mM米索硝唑3天，也不会改变细胞的敏感性。利用大多数实体瘤的生理特性，即，缺氧，以增加肿瘤细胞对细胞毒性剂的敏感性进行了讨论。
Survival of hypoxic cells exposed to misonidazole at 37 degrees C show an initial lag period after which survival decreases exponentially with time. Hypoxic cells incubated with misonidazole for a time equivalent to that of the lag period on the survival curve show increased sensitivity when subsequently given x-irradiation. This is consistent with previously published observations. In addition, preincubation of hypoxic cells with misonidazole ata 37 degrees C also renders cells more sensitive to subsequent treatments by heat or melphalan, mustine and cis-Pt(II). Preincubation must be in hypoxia for cells to become sensitive to a second insult; preincubation in air does not change cellular sensitivity even when this preexposure is 5 mM misonidazole for 3 days. The potential of exploiting a physiological property of most solid tumors, viz., hypoxia, in order to increase sensitivity of tumor cells to cytotoxic agents is discussed.