RK2, a glial-specific homeodomain protein required for embryonic nerve cord condensation and viability in Drosophila.
RK2, a glial-specific homeodomain protein required for embryonic nerve cord condensation and viability in Drosophila.
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发表时间：
1994-10
期刊：
影响因子：
4.6
通讯作者：
Gerard Campbell;Harald H.H. Göring;Tina Lin;E. Spana;S. Andersson;C. Doe;Andrew Tomlinson
中科院分区：
文献类型：
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作者：
Gerard Campbell;Harald H.H. Göring;Tina Lin;E. Spana;S. Andersson;C. Doe;Andrew Tomlinson
我们报告了 RK2（一种神经胶质特异性同源域蛋白）的鉴定。 RK2 定位于几乎所有胚胎和成象神经胶质细胞的细胞核，中线神经胶质细胞除外。编码 RK2 基因的胚胎突变体是胚胎致死的，但早期胶质细胞生成（神经胶质细胞的出生、初始分裂和迁移）和轴突发生（神经元寻路和束束）是正常的。然而，在发育后期，空间杂乱的纵向神经胶质细胞明显减少。此外，轴突束有轻微紊乱，神经索凝结有缺陷。这表明 RK2 不是早期神经胶质细胞测定所必需的，而是胚胎活力所需的神经胶质细胞分化或功能方面所必需的。
We report the identification of RK2, a glial-specific homeodomain protein. RK2 is localized to the nucleus of virtually all embryonic and imaginal glial cells, with the exception of midline glia. Embryos mutant for the gene encoding RK2 are embryonic lethal but normal for early gliogenesis (birth, initial divisions and migration of glia) and axonogenesis (neuronal pathfinding and fasciculation). However, later in development, there are significantly fewer longitudinal glia that are spatially disorganized; in addition, there is a slight disorganization of axon fascicles and a defective nerve cord condensation. This suggests that RK2 is not required for early glial determination, but rather for aspects of glial differentiation or function that are required for embryonic viability.