Extrathyroidal expression of TSH receptor
Extrathyroidal expression of TSH receptor
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DOI：
10.1016/j.ando.2011.03.006
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发表时间：
2011-04-01
影响因子：
3.1
通讯作者：
Williams, G. R.
中科院分区：
文献类型：
--
作者：
Williams, G. R.
甲状腺滤泡细胞表面表达的 TSH 受体在甲状腺状态和甲状腺生长的调节中发挥着关键作用。近年来，很明显 TSH 受体也在多种甲状腺外组织中广泛表达，包括：垂体前叶、下丘脑；子房;睾丸;皮肤;肾;免疫系统;骨髓和外周血细胞；白色和棕色脂肪组织；眼眶前脂肪细胞、成纤维细胞和骨。大量证据正在出现来描述 TSH 受体在这些不同部位的功能作用，但它们在许多情况下的生理重要性仍然是一个有争议和令人感兴趣的话题。讨论了目前对甲状腺外组织中 TSH 受体作用的理解及其可能的生理意义。 (C) 2011 Elsevier Masson SAS。版权所有。
The TSH receptor expressed on the cell surface of thyroid follicular cells plays a pivotal role in the regulation of thyroid status and growth of the thyroid gland. In recent years it has become evident that the TSH receptor is also expressed widely in a variety of extrathyroidal tissues including: anterior pituitary; hypothalamus; ovary; testis; skin; kidney; immune system; bone marrow and peripheral blood cells; white and brown adipose tissue; orbital preadipocyte fibroblasts and bone. A large body of evidence is emerging to describe the functional roles of the TSH receptor at these various sites but their physiological importance in many cases remains a subject of controversy and much interest. Current understanding of the actions of the TSH receptor in extrathyroidal tissues and their possible physiological implications is discussed. (C) 2011 Elsevier Masson SAS. All rights reserved.