Direct cleavage and activation of gasdermin B by allergens.
Direct cleavage and activation of gasdermin B by allergens.
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过敏原直接裂解和激活 Gasdermin B。
作者：
Panganiban,RonaldAllan;Mwase,Chimwemwe;Park,Jin-Ah;Lu,Quan
p <. 05. gl Gasdermin 的裂解释放可诱导细胞焦亡的 N 末端片段。[2]我们研究了 HDM 裂解释放的 244 个氨基酸的 GSDMB-NT 片段（NT-244，图 2D）是否会引发细胞焦亡。这些研究将提供进一步的功能证据，将 GSDMB 介导的细胞焦亡与哮喘联系起来，并可能导致针对过敏原诱导的 GSDMB 裂解和激活的新型哮喘疗法的开发。最近的精细图谱研究已确定 Gasdermin B (I GSDMB i) 是 17q21 基因座中的潜在哮喘易感基因，该基因座是全基因组关联研究中最强且重复性最高的信号。 [1] GSDMB 蛋白是gasdermin 家族的一员，当被切割时，会引发称为细胞焦亡的炎症细胞死亡。 [2] Caspase-1和颗粒酶A已被证明可以在特定位点切割GSDMB，释放出具有诱导包括气道上皮细胞在内的细胞焦亡的能力的蛋白质N端片段（GSDMB-NT）。[[3]]这些研究结果表明，GSDMB在哮喘中的作用在于其能够通过切割被激活以诱导细胞焦亡；然而，目前尚不清楚 GSDMB 裂解和激活是否发生在哮喘的情况下。[摘自文章]Allergy 的版权是 Wiley-Blackwell 的财产，未经版权所有者明确书面许可，不得将其内容复制或通过电子邮件发送到多个网站或发布到列表服务器。但是，用户可以打印、下载或通过电子邮件发送文章供个人使用。本摘要可能会被删节。不保证副本的准确性。用户应参阅该材料的原始发布版本以获取完整摘要。版权适用于所有摘要。
p <. 05. gl Cleavage of gasdermins releases the N-terminal fragments that can induce pyroptotic cell death.[2] We investigated whether the GSDMB-NT fragment of 244 amino acids (NT-244, Figure 2D) released by HDM cleavage triggers pyroptosis. These studies will provide further functional evidence linking GSDMB-mediated pyroptosis to asthma and could lead to the development of novel asthma therapies that target allergen-induced GSDMB cleavage and activation. Recent fine-mapping studies have identified gasdermin B (I GSDMB i) as a potential asthma susceptibility gene in the 17q21 locus, the strongest and most highly replicated signal in genome-wide association studies.[1] The GSDMB protein is a member of the gasdermin family that, when cleaved, triggers an inflammatory cell death known as pyroptosis.[2] Caspase-1 and granzyme A have been shown to cut GSDMB at specific sites to release the N-terminal fragment of the protein (GSDMB-NT) that has the ability to induce pyroptosis in cells, including airway epithelial cells.[[3]] These findings suggest that the role of GSDMB in asthma lies in its ability to be activated through cleavage to induce pyroptosis; however, it remains unclear whether GSDMB cleavage and activation occur in the context of asthma.[Extracted from the article]Copyright of Allergy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. Copyright applies to all Abstracts.