Radioprotective properties of eckol against ionizing radiation in mice
Radioprotective properties of eckol against ionizing radiation in mice
复制标题
DOI：
10.1016/j.febslet.2008.02.031
复制
发表时间：
2008-03-19
期刊：
影响因子：
3.5
通讯作者：
Jee, Youngheun
中科院分区：
文献类型：
--
作者：
Park, Eunjin;Ahn, Gin-nae;Jee, Youngheun
我们研究了棕色海藻埃克洛尼亚洞穴中的一种成分eckol对体内伽玛射线损伤的防护作用。我们的结果表明，eckol显著降低了致死性照射小鼠的死亡率。发现eckol的保护机制包括：促进造血恢复，修复免疫细胞中受损的DNA，促进其增殖，而这一点已被电离辐射严重抑制。因此，我们建议将eckol作为辅助治疗的候选药物，以减轻癌症患者的辐射损伤。(C)2008年欧洲生化学会联合会。爱思唯尔出版，版权所有。
We have investigated the radioprotective efficacy of eckol, a component of brown seaweed Ecklonia cava, against the gamma ray-induced damage in vivo. Our results showed that eckol significantly decreased the mortality of lethally irradiated mice. The mechanisms of eckol's protection were found to include: an improvement in hematopoietic recovery, the repair of damaged DNA in immune cells and an enhancement of their proliferation, which had been severely suppressed by ionizing radiation. Thus, we propose eckol as a candidate for adjuvant therapy to alleviate radiation-induced injuries to cancer patients. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.