The neurogenomic transition from territory establishment to parenting in a territorial female songbird
The neurogenomic transition from territory establishment to parenting in a territorial female songbird
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DOI：
10.1186/s12864-019-6202-3
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发表时间：
2019-11-07
期刊：
影响因子：
4.4
通讯作者：
Rosvall, Kimberly A.
中科院分区：
文献类型：
--
作者：
Bentz, Alexandra B.;Rusch, Douglas B.;Rosvall, Kimberly A.
背景 大脑在交配努力、亲代努力和自我维护的核心过程的上游调节中发挥着关键作用。对于季节性繁殖的动物来说，大脑可能会在短暂的繁殖季节内调节这些过程之间的权衡，但迄今为止的研究仅探索了雄性和/或实验室饲养动物从非繁殖状态到繁殖状态的神经基因组变化或选择途径（例如类固醇）。在这里，我们使用 RNA-seq 来探索三种行为相关神经组织（腹内侧端脑 [VmT]、下丘脑 [HYPO] 和后脑 [HB]）的神经可塑性，比较自由生活的雌性树燕 (Tachycineta bicolor) 从领地建立到孵化的转变。我们还强调了攻击相关基因的变化，以探索调节攻击性的机制发生神经基因组转变的可能性，攻击性是建立和维持领地以及保护后代的关键行为。结果 HB的差异表达基因较少，而VmT和HYPO则有数百个。特别是，VmT 与神经可塑性和有利于领地建立期间竞争的过程相关的基因表达较高，但下调了免疫过程。 HYPO 在孵化过程中表现出高神经可塑性的迹象，并且糖皮质激素信号传导的潜力下降。在整个繁殖季节，攻击相关基因的表达也从类固醇途径转变为非类固醇途径。结论 这些模式表明，VmT 中的增强活动和免疫力之间以及 HYPO 中的压力反应性和父母照顾之间存在权衡，以及调节攻击性的机制可能发生转变。总的来说，这些数据强调了可能构成女性行为可塑性的重要基因调控途径。
Background The brain plays a critical role in upstream regulation of processes central to mating effort, parental effort, and self-maintenance. For seasonally breeding animals, the brain is likely mediating trade-offs among these processes within a short breeding season, yet research thus far has only explored neurogenomic changes from non-breeding to breeding states or select pathways (e.g., steroids) in male and/or lab-reared animals. Here, we use RNA-seq to explore neural plasticity in three behaviorally relevant neural tissues (ventromedial telencephalon [VmT], hypothalamus [HYPO], and hindbrain [HB]), comparing free-living female tree swallows (Tachycineta bicolor) as they shift from territory establishment to incubation. We additionally highlight changes in aggression-related genes to explore the potential for a neurogenomic shift in the mechanisms regulating aggression, a critical behavior both in establishing and maintaining a territory and in defense of offspring. Results HB had few differentially expressed genes, but VmT and HYPO had hundreds. In particular, VmT had higher expression of genes related to neuroplasticity and processes beneficial for competition during territory establishment, but down-regulated immune processes. HYPO showed signs of high neuroplasticity during incubation, and a decreased potential for glucocorticoid signaling. Expression of aggression-related genes also shifted from steroidal to non-steroidal pathways across the breeding season. Conclusions These patterns suggest trade-offs between enhanced activity and immunity in the VmT and between stress responsiveness and parental care in the HYPO, along with a potential shift in the mechanisms regulating aggression. Collectively, these data highlight important gene regulatory pathways that may underlie behavioral plasticity in females.