Oxidative balance score, colorectal adenoma, and markers of oxidative stress and inflammation.
Oxidative balance score, colorectal adenoma, and markers of oxidative stress and inflammation.
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DOI：
10.1158/1055-9965.epi-13-0619
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Goodman M
中科院分区：
文献类型：
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作者：
Kong SY;Bostick RM;Flanders WD;McClellan WM;Thyagarajan B;Gross MD;Judd S;Goodman M
先前报道称，结合促氧化剂和抗氧化剂暴露的氧化平衡评分（OBS）与偶发的散发性结直肠腺瘤有关。我们通过评估 OBS 和结直肠腺瘤与氧化应激（F2-异前列腺素 [FIP] 和荧光氧化产物 [FOP]）和炎症（C 反应蛋白 [CRP]）循环生物标志物的关联来扩展之前的分析。使用先前进行的两项基于结肠镜检查的偶发性、散发性结直肠腺瘤病例对照研究 (n=365) 的汇总数据，构建 OBS 并将其分为三个大致相等的区间，并使用最低区间作为参考。根据对照组的中值，生物标志物水平分为“高”和“低”。使用多变量逻辑回归来计算调整后的比值比 (OR) 和 95% 置信区间 (CI)。对于 OBS-腺瘤关联，中间和最高（相对于最低）评分区间的 OR（95% CI）分别为 0.81（0.46-1.43）和 0.39（0.17-0.89）。相应的 OBS 类别特定 OR（95% CI）对于 FIP 为 0.50（0.25–1.01）和 0.25（0.10–0.65），对于 FOP 为 2.01（1.13–3.75）和 3.48（1.51–8.02），对于 0.57（0.31–1.04）和 0.21 CRP 为 (0.09–0.49)。反映腺瘤与高水平 FIP、FOP 和 CRP 相关性的 OR (95% CI) 分别为 1.89 (1.08–3.30)、1.82 (1.11–2.99) 和 1.45 (0.88–2.40)。正如假设的那样，OBS 与结直肠腺瘤和循环 FIP 和 CRP 水平呈负相关。 OBS-FOP 意外直接关联的原因尚不清楚。这些数据支持在结直肠肿瘤研究中使用促氧化剂和抗氧化剂暴露的联合测量。
An oxidative balance score (OBS) that combines pro- and anti-oxidant exposures was previously reported to be associated with incident sporadic colorectal adenoma. We extend the previous analyses by assessing associations of the OBS and colorectal adenoma with circulating biomarkers of oxidative stress (F2-isoprostanes [FIP] and fluorescent oxidation products [FOP]), and inflammation (C-reactive protein [CRP]). Using pooled data from two previously conducted colonoscopy-based case-control studies of incident, sporadic colorectal adenoma (n=365), the OBS was constructed and divided into three approximately equal intervals, with the lowest interval used as the reference. Biomarker levels were dichotomized as “high” versus “low” based on the median values among controls. Multivariable logistic regression was used to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs). For the OBS-adenoma association, the ORs (95% CIs) for the middle and highest (relative to the lowest) score intervals were 0.81 (0.46–1.43) and 0.39 (0.17–0.89), respectively. The corresponding OBS category-specific ORs (95% CIs) were 0.50 (0.25–1.01) and 0.25 (0.10–0.65) for FIP, 2.01 (1.13–3.75) and 3.48 (1.51–8.02) for FOP, and 0.57 (0.31–1.04) and 0.21 (0.09–0.49) for CRP. The ORs (95% CIs) reflecting associations of adenoma with high levels of FIP, FOP, and CRP were 1.89 (1.08–3.30), 1.82 (1.11–2.99) and 1.45 (0.88–2.40), respectively. As hypothesized, the OBS was inversely associated with colorectal adenoma and circulating FIP and CRP levels. The reason for the unexpected direct OBS-FOP association is unknown. These data support the use of combined measures of pro- and anti-oxidant exposures in studies of colorectal neoplasia.