Bone mineral content of the lumbar spine in normal and osteoporotic women: cross-sectional and longitudinal studies.
Bone mineral content of the lumbar spine in normal and osteoporotic women: cross-sectional and longitudinal studies.
复制标题
正常和骨质疏松女性腰椎的骨矿物质含量：横断面和纵向研究。
作者：
B. Krølner;S. P. Nielsen
1. 采用双光子（153Gd）吸收法测定正常女性和临床骨质疏松症女性第二、第三、第四腰椎骨矿物质含量。2. 一项对70名正常人（19-88岁）的横断面研究显示，从34岁左右开始，一生中骨质流失的比例为44%。3. 59名正常女性的纵向数据证实，椎体骨质流失始于绝经前。绝经后，骨质流失速度加快，每年接近6%。老年妇女的骨质流失速度较慢。4. 36名女性（年龄48-93岁）股骨颈轻度外伤后骨折，其腰椎骨矿物质含量与同龄正常女性相当。股骨粗隆内骨折患者的腰椎骨矿物质含量低于股骨内侧骨折患者。5. 72名患有原发性骨质疏松症的女性（年龄在58-59岁之间）腰部骨矿物质的平均含量比正常绝经前女性低41%，比同龄对照组低18%。腰椎骨矿物质含量与压缩性骨折数量呈弱反比关系。腰椎骨矿物质含量与压缩性骨折数量呈弱反比关系。6. 腰椎骨矿物质含量低于正常绝经前妇女95%置信限的妇女将来有椎体压缩性骨折的风险，骨折风险与腰椎骨矿物质含量成反比。
1. Bone mineral content of the second, third and fourth lumbar vertebrae was determined in normal women and women with clinical osteoporosis by using dual-photon (153Gd) absorption. 2. A cross-sectional study of 70 normal (aged 19-88 years) showed a bone loss of 44% from the age of around 34 years throughout life. 3. Longitudinal data from 59 normal women confirmed that the vertebral bone loss started before the menopause. An accelerated bone loss amounting to nearly 6% per year was seen immediately after the menopause. The bone loss of older women was slower. 4. Mean lumbar bone mineral content of 36 women (aged 48-93 years) with recent fractures of their femoral neck after minor trauma equalled that of aged-matched normal women. Lumbar bone mineral content of the women with intratrochanteric femoral neck fractures was lower than that of the women with medial femoral neck fractures. 5. Mean lumbar bone mineral content of 72 women (aged 58-59 years) with primary osteoporosis was 41% lower than that of normal premenopausal women and 18% lower than that of age-matched controls. A weak inverse relationship between lumbar bone mineral content and the number of compression fractures was found. A weak inverse relationship between lumbar bone mineral content and the number of compression fractures was found. 6. Women with lumbar bone mineral content values below the 95% confidence limits for normal premenopausal women are at risk of future vertebral compression fractures, the fracture risk being inversely related to lumbar bone mineral content.