Regional gray matter reduction correlates with subjective quality of life in schizophrenia.
Regional gray matter reduction correlates with subjective quality of life in schizophrenia.
复制标题
区域灰质减少与精神分裂症患者的主观生活质量相关。
DOI：
10.1016/j.jpsychires.2013.01.002
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发表时间：
2013
影响因子：
4.8
通讯作者：
T.
中科院分区：
文献类型：
--
作者：
Ubukata;S.;Miyata;J.;Yoshizumi;M.;Uwatoko;T.;Hirao;K.;Fujiwara;H.;Kawada;R.;Fujimoto;S.;Tanaka;Y.;Kubota;M.;Sasamoto;A.;Sawamoto;N.;Fukuyama;H.;Takahashi;H.;& Murai;T.
主观生活质量（QOL）已被认为是精神分裂症的重要考虑因素。一些症状和神经认知功能被证明与主观生活质量相关；然而其决定因素尚不清楚。在这项研究中，我们调查了精神分裂症患者大脑结构异常与主观生活质量之间的关联。 45 名精神分裂症患者和 48 名年龄、性别和教育程度匹配的健康参与者接受了磁共振成像 (MRI)，并使用精神分裂症生活质量量表 (SQLS) 来评估主观生活质量。我们进行了基于体素的形态测量（VBM）来研究区域大脑变化。与正常对照相比，精神分裂症患者的灰质减少主要集中在额叶和颞区。 SQLS 的心理社会分量表较差与右侧背外侧前额叶皮层 (DLPFC) 灰质 (GM) 减少相关，动机/能量分量表较差与左额上沟、左侧海马旁回和左侧颞下回灰质减少相关。在控制精神病理学的严重程度后，DLPFC GM 体积与 SQLS 心理社会分量表之间的相关性消失，而在控制人口统计学和临床变量时，其他相关性仍然显着。将成像技术与心理社会方法相结合将有助于阐明与生活质量相关的因素。
Subjective quality of life (QOL) has been recognized as an important consideration in schizophrenia. Several symptoms and neurocognitive functions were shown to be correlated with subjective QOL; however its determinants are not well understood. In this study, we investigated the association between brain structural abnormalities and subjective QOL in patients with schizophrenia. Forty-five schizophrenia patients and 48 age, sex, and education-matched healthy participants underwent magnetic resonance imaging (MRI), and the Schizophrenia Quality of Life Scale (SQLS) was used to rate subjective QOL. We performed voxel-based morphometry (VBM) to investigate regional brain alterations. Relative to normal controls, schizophrenia patients exhibited gray matter reductions mainly in the frontal and temporal regions. Worse psychosocial subscale of SQLS was associated with gray matter (GM) reduction in the right dorsolateral prefrontal cortex (DLPFC), and worse motivation/energy subscale was associated with gray matter reduction in the left superior frontal sulcus, left parahippocampal gyrus, and the left inferior temporal gyrus. The correlation between DLPFC GM volume and psychosocial subscale of SQLS disappeared after controlling for severity of psychopathology, while the other correlations remained significant when controlled by demographic and clinical variables. Combining imaging techniques with psychosocial methods would help to elucidate those factors that are associated with QOL.