Laminar sources of synaptic input to cortical inhibitory interneurons and pyramidal neurons
Laminar sources of synaptic input to cortical inhibitory interneurons and pyramidal neurons
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DOI：
10.1038/76656
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发表时间：
2000-07-01
影响因子：
25
通讯作者：
Callaway, EM
中科院分区：
文献类型：
--
作者：
Dantzker, JL;Callaway, EM
单个神经元在皮质回路中的功能作用在很大程度上取决于该神经元的突触输入。我们用激光扫描光刺激技术研究了大鼠视皮层2/3层皮质神经元亚型的局部输入的层流源。我们确定了三种不同的兴奋性输入层流模式，对应于神经元的生理和形态亚型。快峰抑制篮细胞和兴奋性锥体神经元接受来自皮质中层的强兴奋性输入。相反，适应性抑制性中间神经元从深层或从2/3层的侧向获得最强的兴奋性输入。因此，不同的兴奋性输入的层流来源有助于皮质抑制性中间神经元功能的多样性。
The functional role of an individual neuron within a cortical circuit is largely determined by that neuron's synaptic input. We examined the laminar sources of local input to subtypes of cortical neurons in layer 2/3 of rat visual cortex using laser scanning photostimulation. We identified three distinct laminar patterns of excitatory input that correspond to physiological and morphological subtypes of neurons. Fast-spiking inhibitory basket cells and excitatory pyramidal neurons received strong excitatory input from middle cortical layers. In contrast, adapting inhibitory interneurons received their strongest excitatory input either from deep layers or laterally from within layer 2/3. Thus, differential laminar sources of excitatory inputs contribute to the functional diversity of cortical inhibitory interneurons.