Advantage of Next-Generation Frequency-Domain Optical Coherence Tomography Compared with Conventional Time-Domain System in the Assessment of Coronary Lesion
Advantage of Next-Generation Frequency-Domain Optical Coherence Tomography Compared with Conventional Time-Domain System in the Assessment of Coronary Lesion
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DOI：
10.1002/ccd.22273
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发表时间：
2010-02-01
影响因子：
2.3
通讯作者：
Akasaka, Takashi
中科院分区：
文献类型：
--
作者：
Takarada, Shigeho;Imanishi, Toshio;Akasaka, Takashi
背景：冠状动脉内光学相干断层扫描（OCT）是一种用于评估冠状动脉病变形态的高分辨率成像方式。然而，当前的时域 OCT (TD-OCT) 在临床环境中的程序使用和安全性方面存在许多限制。下一代频域OCT（FD-OCT）具有比TD-OCT快得多的帧速率和回拉速度，有望克服这些限制。本研究的目的是评估下一代 FD-OCT 在评估冠状动脉病变中的可行性和可用性。方法：对 14 例缺血性心脏病患者植入 20 个冠状动脉支架，从可用性（设置时间）、定性（清晰图像片段率）和安全性（不良事件）方面对 FD-OCT 和 TD-OCT 进行比较研究。结果：本研究中从设置到完成图像采集的 OCT 过程的平均时间（FD-OCT）为 3.2 +/- 0.8 分钟，TD-OCT 为 11.2 +/- 2.5 分钟（P < 0.01）。在定性图像评估中，FD-OCT 有可能比 TD-OCT 产生更高的清晰图像片段 (CIS) 率（分别为 99.4% 和 80.8%；P < 0.01）。除了这些改善的特征外，没有出现与 FD-OCT 相关的缺血性心电图变化或心律失常。结论：下一代冠状动脉内 FD-OCT 在临床环境中具有更好的性能，并且有可能克服传统 TD-OCT 系统的一些局限性。 (C) 2009 Wiley-Liss, Inc.
Background: Intracoronary optical coherence tomography (OCT) is a high-resolution imaging modality used for evaluation of coronary lesion morphology. However, current time-domain OCT (TD-OCT) have a number of limitations with regard to both procedural usage and safety in the clinical setting. The next-generation frequency-domain OCT (FD-OCT), which has a much faster frame rate and pullback speed than TD-OCT, is expected to overcome these limitations. The aim of this study was to evaluate the feasibility and usability of next generation FD-OCT in the assessment of coronary lesions. Methods: A comparison study was performed between FD-OCT and TD-OCT from the aspect of usability (set-up time), qualitatively (rate of clear image segment), and safety (adverse event) in 14 ischemic heart disease patients with 20 previously implanted coronary stents. Results: The mean time of the OCT procedure in this study from setup to completion of image acquisition was 3.2 +/- 0.8 min for FD-OCT and 11.2 +/- 2.5 min for TD-OCT (P < 0.01). In qualitative image assessment, FD-OCT has the potential to yield a higher rate of clear image segments (CIS) than TD-OCT (99.4% vs. 80.8%, respectively; P < 0.01). In addition to these improved characteristics, there were no ischemic ECG changes or arrhythmia associated with FD-OCT. Conclusions: The next-generation intracoronary FD-OCT has better performance in the clinical setting and the potential to overcome several limitations of conventional TD-OCT systems. (C) 2009 Wiley-Liss, Inc.