QUANTITATIVE HISTOLOGICAL DATA ON DISUSE OSTEOPOROSIS
QUANTITATIVE HISTOLOGICAL DATA ON DISUSE OSTEOPOROSIS
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DOI：
10.1007/bf02547214
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发表时间：
1974-01-01
期刊：
影响因子：
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通讯作者：
BOURRET, J
中科院分区：
文献类型：
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作者：
MINAIRE, P;MEUNIER, P;BOURRET, J
通过对34例脱钙和未脱钙髂嵴活检标本进行纵向、横断面、定量和动态组织学分析，研究制动对人体骨的影响。他们获得了在不同的时间后，发病的制动28例，其中22例患有创伤后脊髓病变。测量骨小梁体积、类骨质体积、骨小梁骨吸收表面、骨膜骨陷窝大小、髂骨皮质厚度和骨髓细胞群体积。用四环素双标记法对19例进行了组织动力学研究。将组织学数据与另一组68例固定患者（包括22例接受活检的患者）的生物学数据进行比较。测定血钙、血磷、碱性磷酸酶、尿钙、尿磷酸盐和羟脯氨酸尿。骨小梁体积在25周内平均减少33%，然后趋于稳定。制动也导致早期增加骨小梁骨吸收表面，后来在骨膜骨陷窝的大小，早期抑郁症的成骨细胞骨形成和变薄的皮质。钙尿高，羟脯氨酸尿与吸收表面相关。组织学和生物化学的变化表明，根据组织动力学假说，BMU（弗罗斯特的基本多细胞单位）的整体寿命将增加。这些变化反映了一种暂时性的，导致了一种新的稳定状态：骨质疏松，随后的转换率很低。他们强调机械因素在骨细胞发育中的重要性。
The effect of immobilization on human bone was studied through a longitudinal, as well as cross-sectional, quantitative and dynamic histological analysis of 34 decalcified and undecalcified iliac crest biopsies. They were obtained at various times after the onset of immobilization in 28 patients of which 22 were suffering from post-traumatic spinal cord lesions. Trabecular bone volume, osteoid volume, trabecular osteoclastic resorption surfaces, size of the periosteocytic lacunae, thickness of iliac cortices and volume of the cell population of the marrow were measured. The histodynamic study was made by double tetracycline labeling in 19 patients. The histological data were compared with biological data from another group of 68 immobilized patients including 22 of the patients undergoing biopsy. Calcemia, phosphoremia, alkaline phosphatase, calciura, phosphaturia and hydroxyprolinuria were measured. The decrease of the trabecular bone volume averaged 33% over 25 weeks and then stabilized. Immobilization also caused an early increase in the trabecular osteoclastic resorption surfaces and later in the size of periosteocytic lacunae, an early depression of osteoblastic bone formation and a thinning of the cortices. Calciuria was high, as was hydroxyprolinuria which correlates with resorption surfaces. The histological and biochemical changes suggest an histodynamic hypothesis according to which the global lifespan of the BMU (Basic Multicellular Unit from Frost) would be increased. These changes reflect atransient, leading to a newsteady state: rarefied bone with a low rate of subsequent turn-over. They emphasize the importance of mechanical factors in the development of bone cells.