Replication analysis of SNPs on 9p21.2 and 19p13.3 with amyotrophic lateral sclerosis in East Asians
Replication analysis of SNPs on 9p21.2 and 19p13.3 with amyotrophic lateral sclerosis in East Asians
复制标题
东亚人肌萎缩侧索硬化症 9p21.2 和 19p13.3 上的 SNP 复制分析
DOI：
10.1016/j.neurobiolaging.2010.12.011
复制
发表时间：
2011-04
影响因子：
4.2
通讯作者：
Ikegawa S
中科院分区：
文献类型：
--
作者：
Akimoto C;Nakajima M;Kubo M;Kamatani N;Nakano I;Sobue G;Nakamura Y;Fan D;Ikegawa S
我们对最近报道的与白种人散发性肌萎缩性侧索硬化症（ALS）最显著相关的2个遗传变异rs2814707 （9p21.2）和rs12608932 （19p13.3）进行了复制研究。rs12608932和rs2814707在日本和中国均未显示相关性（rs12608932，合并p = 0.58，优势比[OR] = 1.03, 95%可信区间[CI] 0.93-1.13; rs2814707，合并p = 0.88, OR = 1.10, 95%可信区间[CI] 0.93-1.30）。这些基因位点与散发性ALS易感性的关联在东亚被认为是阴性的。
We performed a replication study of the 2 genetic variants, rs2814707 on 9p21.2 and rs12608932 on 19p13.3 that are recently reported to be most significantly associated with sporadic amyotrophic lateral sclerosis (ALS) in Caucasians. Both rs12608932 and rs2814707 showed no evidence of association in Japanese and Chinese (rs12608932, combined p = 0.58, odds ratio [OR] = 1.03, 95% confidence interval [CI] 0.93–1.13; rs2814707, combined p = 0.88, OR = 1.10, 95% CI 0.93–1.30). The association of these loci with susceptibility to sporadic ALS is considered negative in East Asians.
影响因子：
30.8
作者：
van Es, Michael A.;Veldink, Jan H.;van den Berg, Leonard H.
通讯作者：
van den Berg, Leonard H.