Cognitive impairment in late-life generalized anxiety disorder
Cognitive impairment in late-life generalized anxiety disorder
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DOI：
10.1097/jgp.0b013e31803111f2
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发表时间：
2007-08-01
影响因子：
7.2
通讯作者：
Lenze, Eric J.
中科院分区：
文献类型：
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作者：
Mantella, Rose C.;Butters, Meryl A.;Lenze, Eric J.
本研究旨在将患有广泛性焦虑症（GAD）的老年患者的认知功能与正常对照受试者和重度抑郁症患者进行比较。方法：使用马蒂斯痴呆评定量表以及命名、执行能力和记忆等特定领域来评估 GAD（N = 19）的认知功能，并与晚年重度抑郁症（MDD；N = 68）和无精神疾病（N = 40）进行比较。结果：与健康正常对照受试者相比，焦虑受试者的短期记忆和延迟记忆测量受到损害。抑郁症受试者在记忆延迟和命名方面也比正常对照受试者表现更差。在任何认知功能测量中，焦虑受试者与抑郁受试者没有显着差异。结论：在这项初步研究中，焦虑受试者表现出短期记忆认知障碍；与正常对照受试者相比，抑郁症患者表现出执行功能障碍和更普遍的认知障碍，而焦虑受试者则不明显。对老年焦虑受试者的神经心理功能的研究可能有助于制定缓解认知功能障碍并阐明病程和潜在神经通路的治疗干预措施。
This study sought to characterize cognitive functioning in elderly patients with generalized anxiety disorder ( GAD), as compared with normal comparison subjects and patients with major depression. Methods: The cognitive functioning in GAD ( N = 19) was assessed with the Mattis Dementia Rating Scale and across specific domains of naming, executive ability, and memory, in comparison with late-life major depressive disorder ( MDD; N = 68) and versus no psychiatric illness ( N = 40). Results: In comparison to healthy normal comparison subjects, anxious subjects were impaired on measures of short-term and delayed memory. Depressed subjects also performed worse than normal comparison subjects on delayed memory, as well as in naming. Anxious subjects did not differ significantly from depressed subjects in any measure of cognitive function. Conclusion: In this preliminary study, anxious subjects displayed cognitive impairments in short-term memory; while depressed patients compared to normal comparison subjects showed executive dysfunction and more general cognitive impairments not evident in anxious subjects. Studies of neuropsychological function in elderly anxious subjects may be informative in developing treatment interventions that mitigate cognitive dysfunction and illuminate the course of illness and underlying neural pathways.