The Role of Pathogens and Anti-Infective Agents in Parkinson's Disease, from Etiology to Therapeutic Implications.
The Role of Pathogens and Anti-Infective Agents in Parkinson's Disease, from Etiology to Therapeutic Implications.
复制标题
病原体和抗感染药物在帕金森病中的作用，从病因到治疗意义
DOI：
10.3233/jpd-212929
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Shi CH
中科院分区：
文献类型：
--
作者：
Shen S;Zhang C;Xu YM;Shi CH
帕金森氏症是一种衰弱的神经退行性疾病，其病因尚不清楚，阻碍了有效治疗方法的发展。迫切需要确定病因并提供进一步有效的治疗。最近，越来越多的证据表明，感染可能在帕金森病的病因中发挥作用。感染性病原体可能是帕金森氏症的诱因，其中最常见的是丙型肝炎病毒、流感病毒和幽门螺杆菌。此外，肠道微生物区系通过肠道-脑轴影响脑功能，在帕金森氏病的发病机制中发挥重要作用。此外，一系列抗感染药物通过不同的机制显示出惊人的神经保护作用，如干扰α-突触核蛋白聚集，抑制神经炎症，减轻氧化应激，防止细胞死亡，而不是依赖于它们的抗菌作用。多效性药物在帕金森病的发病机制中发挥重要作用。此外，它们中的大多数毒性较小，临床安全，具有良好的血脑渗透性，使它们成为治疗帕金森氏症的有希望的候选药物。然而，抗生素的使用和随后的肠道生物失调也可能在帕金森病中发挥作用，这使得抗感染药物的长期效果值得进一步考虑和探索。本文综述了感染性病原体与帕金森病关系的现有证据，并对抗感染药物在帕金森病治疗中的应用前景进行了探讨，为帕金森病的发病机制和治疗提供了新的见解。
Parkinson’s disease is a debilitating neurodegenerative disorder whose etiology is still unclear, hampering the development of effective treatments. There is an urgent need to identify the etiology and provide further effective treatments. Recently, accumulating evidence has indicated that infection may play a role in the etiology of Parkinson’s disease. The infective pathogens may act as a trigger for Parkinson’s disease, the most common of which are hepatitis C virus, influenza virus, and Helicobacter pylori. In addition, gut microbiota is increasingly recognized to influence brain function through the gut-brain axis, showing an important role in the pathogenesis of Parkinson’s disease. Furthermore, a series of anti-infective agents exhibit surprising neuroprotective effects via various mechanisms, such as interfering with α-synuclein aggregation, inhibiting neuroinflammation, attenuating oxidative stress, and preventing from cell death, independent of their antimicrobial effects. The pleiotropic agents affect important events in the pathogenesis of Parkinson’s disease. Moreover, most of them are less toxic, clinically safe and have good blood-brain penetrability, making them hopeful candidates for the treatment of Parkinson’s disease. However, the use of antibiotics and subsequent gut dysbiosis may also play a role in Parkinson’s disease, making the long-term effects of anti-infective drugs worthy of further consideration and exploration. This review summarizes the current evidence for the association between infective pathogens and Parkinson’s disease and subsequently explores the application prospects of anti-infective drugs in Parkinson’s disease treatment, providing novel insights into the pathogenesis and treatment of Parkinson’s disease.