Di(2-ethylhexyl)phthalate but not phenobarbital promotes N-nitrosodiethylamine-initiated hepatocellular proliferative lesions after short-term exposure in male B6C3F1 mice.
Di(2-ethylhexyl)phthalate but not phenobarbital promotes N-nitrosodiethylamine-initiated hepatocellular proliferative lesions after short-term exposure in male B6C3F1 mice.
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雄性 B6C3F1 小鼠短期暴露后，邻苯二甲酸二（2-乙基己基）酯而非苯巴比妥会促进 N-亚硝基二乙胺引发的肝细胞增殖性病变。
DOI：
10.1016/0304-3835(84)90079-x
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发表时间：
1984
期刊：
影响因子：
9.7
通讯作者：
Riggs,C
中科院分区：
文献类型：
--
作者：
Ward,JM;Ohshima,M;Lynch,P;Riggs,C
在雄性B6C3F1小鼠中研究了短期或长期暴露于肝脏肿瘤促进剂邻苯二甲酸二（2-乙基己基）酯（DEHP）或苯巴比妥（PB）的不同影响。小鼠在4周龄时腹腔注射n -亚硝基二乙胺（DEN），剂量为80 mg/kg。5周龄时，分别饲喂含PB或DEHP的日粮1 ~ 168天，于168天或252天处死。当DEHP以3000 ppm的膳食水平喂养28、84或168天，或PB在500 ppm的水中喂养168天时，与单独接受DEN的小鼠相比，小鼠局灶性肝细胞增殖性病变（FHPL）的发生率显著增加。饲喂DEHP 1、7 d和PB 1、7、28、84 d对FHPL无显著促进作用。因此，DEHP仅在28天、84天或168天暴露后就成为有效的促进剂，而PB则需要连续暴露168天才能产生明显的促进作用。
The differential effects of short- or long-term exposure to the liver tumor promoters di(2-ethylhexyl)phthalate (DEHP) or phenobarbital (PB) were studied in male B6C3F1 mice. Mice were injected intraperitoneally (i.p.) at 4 weeks of age withN-nitrosodiethylamine (DEN) at a dosage of 80 mg/kg. At 5 weeks of age, the mice were fed diets containing PB or DEHP for periods of from 1 to 168 days and killed at 168 or 252 days. When DEHP was fed at a dietary level of 3000 ppm for 28, 84, or 168 days, or PB was fed in the water at 500 ppm for 168 days, there were significantly increased incidences of mice with focal hepatocellular proliferative lesions (FHPL) as compared with those in mice receiving DEN alone. There was no significant promotion of FHPL when DEHP was fed for 1 or 7 days or when PB was fed for 1, 7, 28, or 84 days. Thus, DEHP was an effective promoter after only 28, 84, or 168 days exposure whereas PB required 168 days of continuous exposure for a promotive effect to be evident.