Kremen1 regulates the regenerative capacity of support cells and mechanosensory hair cells in the zebrafish lateral line.
Kremen1 regulates the regenerative capacity of support cells and mechanosensory hair cells in the zebrafish lateral line.
复制标题
Kremen1调节斑马鱼侧线支持细胞和机械感觉毛细胞的再生能力。
DOI：
10.1016/j.isci.2023.108678
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发表时间：
2024-01-19
期刊：
影响因子：
5.8
通讯作者：
McGraw, Hillary F.
中科院分区：
文献类型：
--
作者：
Megerson, Ellen;Kuehn, Michael;Leifer, Ben;Bell, Jon M.;Snyder, Julia L.;McGraw, Hillary F.
在水生脊椎动物特殊的侧线感觉系统中，内耳的机械感觉毛细胞调节听觉和平衡的感觉，以及水运动的感觉。在哺乳动物中，毛细胞在受损后缺乏再生能力，导致感觉障碍。相比之下，非哺乳类脊椎动物，如斑马鱼，可以在整个生命周期内更新毛细胞。WNT信号是内耳和侧线毛细胞发育所必需的，并调节再生。Kremen1抑制Wnt信号和毛细胞的形成，尽管它在再生中的作用尚不清楚。我们使用斑马鱼kremen1突变系显示了过度激活的Wnt信号导致额外的支持细胞和毛细胞再生而没有增加增殖，这与之前描述的Wnt信号在毛细胞再生中的作用形成了对比。这项工作使我们能够了解机械感觉毛细胞的生物学，以及损伤后如何促进再生。Kremen1突变体具有额外侧线毛细胞的发育和再生额外毛细胞的再生独立于增殖的变化而发生背部支持细胞在Kremen1突变体侧线神经肥大中扩张Wnt信号调节侧线毛细胞前体细胞的稳定生理学；分子生物学；细胞生物学
Mechanosensory hair cells in the inner ear mediate the sensations of hearing and balance, and in the specialized lateral line sensory system of aquatic vertebrates, the sensation of water movement. In mammals, hair cells lack the ability to regenerate following damage, resulting in sensory deficits. In contrast, non-mammalian vertebrates, such as zebrafish, can renew hair cells throughout their lifespan. Wnt signaling is required for development of inner ear and lateral line hair cells and regulates regeneration. Kremen1 inhibits Wnt signaling and hair cell formation, though its role in regeneration is unknown. We used a zebrafish kremen1 mutant line to show overactive Wnt signaling results in supernumerary support cells and hair cell regeneration without increased proliferation, in contrast with the previously described role of Wnt signaling during hair cell regeneration. This work allows us to understand the biology of mechanosensory hair cells and how regeneration might be promoted following damage. Kremen1 mutants have supernumerary lateral line hair cell development and regeneration Supernumerary hair cell regeneration occurs independently of changes in proliferation Dorsoventral support cells are expanded in Kremen1 mutant lateral line neuromasts Wnt signaling regulates poised hair cell progenitors in the lateral line Physiology; Molecular biology; Cell biology
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影响因子：
2.5
作者：
Head, Jeffery R.;Gacioch, Leah;Meyers, Jason R.
通讯作者：
Meyers, Jason R.
DOI：
10.1007/s10162-002-3022-x
发表时间：
2003-06-01
影响因子：
2.4
作者：
Harris, JA;Cheng, AG;Rubel, EW
通讯作者：
Rubel, EW
影响因子：
2.9
作者：
Brignull HR;Raible DW;Stone JS
通讯作者：
Stone JS
影响因子：
2.9
作者：
Lie, Arve;Skogstad, Marit;Tambs, Kristian
通讯作者：
Tambs, Kristian
影响因子：
11.8
作者：
Baek, Sungmin;Tran, Nhung T. T.;Diaz, Daniel C.;Tsai, Ya-Yin;Acedo, Joaquin Navajas;Lush, Mark E.;Piotrowski, Tatjana
通讯作者：
Piotrowski, Tatjana