Hypertension promotes coronary calcium deposit in asymptomatic men
Hypertension promotes coronary calcium deposit in asymptomatic men
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DOI：
10.1161/01.hyp.27.4.949
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发表时间：
1996-04-01
期刊：
影响因子：
8.3
通讯作者：
Levenson, J
中科院分区：
文献类型：
--
作者：
Megnien, JL;Simon, A;Levenson, J
尽管冠状动脉粥样硬化在冠状动脉疾病中发挥重要作用，但其在无并发症高血压中的研究却很少。因此，我们通过超快计算机断层扫描评估了 73 对年龄匹配的无症状高血压或血压正常男性的冠状动脉钙的存在和含量（评分）。我们还根据具有超声斑块的动脉部位（颈动脉、主动脉、股动脉）的数量来估计外周动脉粥样硬化的程度。与血压正常的男性相比，高血压男性的冠状动脉钙化频率更高（63% vs 47%），钙评分较高（57+/-111 vs 18+/-38），钙沉积的比值比为 1.95（置信区间 [CI] 95%，1.01 至 3.79），任何评分为 2.38（95% CI，1.02 至 5.52）或分数高于 50 或 100 时分别为 4.84（95% CI，1.53 至 15.3）。高血压男性显示钙评分与年龄和高血压持续时间相关，但与血压高度无关，广泛和轻微外周动脉粥样硬化之间钙沉积的比值比为 4.67（95% CI，1.41 至 15.45），任何评分为 8.63（95% CI，2.10 至 35.5）或 8.13（95% CI，1.64 至 15.45）。 40.3）对于分数高于 50 或 1001。因此，高血压，特别是其持续时间而不是其值，会促进冠状动脉钙的存在和总体范围，与外周动脉粥样硬化的程度平行，冠状动脉钙是冠心病猝死的潜在预测因子。高血压和冠状动脉钙化相互作用的机制可能是多因素的，并且并非高血压所特有的。
Despite its important role in coronary disease, coronary atherosclerosis has been poorly investigated in uncomplicated hypertension. Therefore, we evaluated the presence and amount (score) of coronary calcium with ultrafast computed tomography in 73 pairs of age-matched asymptomatic hypertensive or normotensive men. We also estimated the extent of peripheral atherosclerosis as the number of arterial sites (carotid, aortic, femoral) with echographic plaque. Compared with normotensive men, hypertensive men had more frequent coronary calcium (63% versus 47%), a higher calcium score (57+/-111 versus 18+/-38), and an odds ratio of calcium deposit of 1.95 (with confidence intervals [CI] 95%, 1.01 to 3.79) for any score and of 2.38 (95% CI, 1.02 to 5.52) or 4.84 (95% CI, 1.53 to 15.3) for scores above 50 or 100, respectively. Hypertensive men showed correlations of calcium score with age and hypertension duration but nor with the height of blood pressure, and the odds ratio of calcium deposit between extensive and minor peripheral atherosclerosis was 4.67 (95% CI, 1.41 to 15.45) for any score and 8.63 (95% CI, 2.10 to 35.5) or 8.13 (95% CI, 1.64 to 40.3) for scores above 50 or 1001. Thus, high blood pressure and in particular its duration rather than its value promotes the presence and overall extent of coronary calcium, a potential predictor of sudden coronary death, in parallel with the extent of peripheral atherosclerosis. The mechanisms of the interaction of hypertension and coronary calcification may be multifactorial and not specific to hypertension.