High prevalence of hypophosphataemia amongst patients with infectious diseases.: A retrospective study
High prevalence of hypophosphataemia amongst patients with infectious diseases.: A retrospective study
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DOI：
10.1046/j.1365-2796.1999.00540.x
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发表时间：
1999-07-01
影响因子：
11.1
通讯作者：
Nilsson, M
中科院分区：
文献类型：
--
作者：
Håglin, L;Burman, LÅ;Nilsson, M
目标：描述 1993 年期间接受传染病治疗的所有患者中低磷酸盐血症的患病率。在低磷血症患者中研究了血清 C 反应蛋白、血清白蛋白和血液中白细胞之间的关联。根据感染的严重程度进行比较设计。低磷酸盐血症患病率的回顾性研究，以及亚组患者的病例对照研究。设置。瑞典于默奥大学医院传染病科。科目。患病率研究纳入了 1993 年接受治疗的所有 967 名患者（449 名女性和 518 名男性）。在病例对照研究中，纳入了108例血清磷酸盐小于或等于0.64 mmol L-1的病例，以及216例年龄和性别匹配的血清磷酸盐> 0.82 nmol L-1（男性）和> 0.86 mmol L-1（女性）的对照。结果，在967名患者中，有402名（42％）至少有一个血清磷酸盐值低于参考水平， 1966 份血液样本中有 573 份（29%）被发现存在低磷酸血症。 1.2% 的患者（占血液样本的 0.9%）出现严重低磷酸血症（< 0.30 mmol L-1）。女性低磷酸盐血症的患病率高于男性。在病例对照研究中，病例中的血清 C 反应蛋白和白细胞数量高于对照组（分别为 124 vs. 94 mg L-1 和 11.4 vs. 9.3 cells/L，x 10(9)）。多元Logistic回归显示，与轻度感染患者相比，严重感染患者出现低血清磷的风险高出4倍，其他变量（白蛋白、住院天数或血液中的白细胞）均不会增加低磷血症的风险。 结论，本研究显示的低血清磷水平的高患病率以及严重感染者出现低磷水平的风险增加需要进一步关注。
Objectives, To describe the prevalence of hypophosphataemia amongst all patients treated during 1993 for infectious diseases. The associations between serum C-reactive protein, serum albumin and white blood cells in blood were studied amongst hypophosphataemic patients. Comparisons were made according to the severity of infection.Design. A retrospective study of the prevalence of hypophosphataemia, and a case-control study amongst a subgroup of patients.Setting. The Department of Infectious Diseases, University Hospital, Umea, Sweden.Subjects. For the prevalence study all 967 patients (449 women and 518 men) treated during 1993 were included. In the case-control study, 108 cases, with serum phosphate less than or equal to 0.64 mmol L-1, 216 age-and sex-matched controls with serum phosphate > 0.82 nmol L-1 (men) and > 0.86 mmol L-l (women), respectively, were included.Results, In 402 of 967 patients (42%) at least one serum phosphate value was below the reference level, Hypophosphataemia was found in 573 of 1966 blood samples (29%). Severe hypophosphataemia (< 0.30 mmol L-1) was seen in 1.2% of the patients (0.9% of blood samples). The prevalence of hypophosphataemia was higher amongst women than amongst men. In the case-control study, the serum C-reactive protein and the number of white blood cells was higher amongst the cases compared with the controls (124 vs. 94 mg L-1 and 11.4 vs. 9.3 cells/L, x 10(9), respectively). The multiple logistic regression showed a 4-fold higher risk of having low serum phosphate in patients with severe infection, compared with mild infections, None of the other variables (albumin, days of hospital stay or white blood cells in blood) increased the risk for hypophosphataemia.Conclusions, The high prevalence of low serum phosphate levels and the increased risk of having low levels in severe infections shown in this study needs further attention.