GM1 antibodies in post-polio syndrome and previous paralytic polio
GM1 antibodies in post-polio syndrome and previous paralytic polio
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DOI：
10.1016/s0165-5728(03)00123-1
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发表时间：
2003-06-01
影响因子：
3.3
通讯作者：
Vedeler, CA
中科院分区：
文献类型：
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作者：
Farbu, E;Rekand, T;Vedeler, CA
我们研究了脊髓灰质炎后综合征(PPS)和GM1抗体之间的关系，因为这种抗体与PPS和运动神经元疾病有关。用双抗体夹心ELISA法对144例既往脊髓灰质炎患者(瘫痪105例，非麻痹22例，PPS 17例)、60例既往格林-巴利综合征患者、44例肌萎缩侧索硬化症(ALS)患者和22例健康献血员血清进行GM1-IgM-Ig G和Ig A抗体检测。14%的PPS患者存在GM1抗体，但患病率与其他组没有显著差异。我们的研究不支持GM1抗体参与PPS发病机制的假设。(C)2003 Elsevier Science B.V.保留所有权利。
We studied the relationship between post-polio syndrome (PPS) and GM1 antibodies, since such antibodies have been associated with PPS and motor neuron disorders. Sera from 144 patients with previous poliomyelitis (105 paralytic, 22 nonparalytic and 17 PPS), 60 with previous Guillain-Barre syndrome, 44 with amyotrophic lateral sclerosis (ALS) and 22 healthy blood donors were analyzed with ELISA for GM1 IgM IgG and IgA antibodies. GM1 antibodies were present in 14% of the PPS patients, but the prevalence did not differ significantly from that of the other groups. Our study does not support the hypothesis that GM1 antibodies are involved in the pathogenesis of PPS. (C) 2003 Elsevier Science B.V. All rights reserved.