A REQUIREMENT FOR BONE MORPHOGENETIC PROTEIN-7 DURING DEVELOPMENT OF THE MAMMALIAN KIDNEY AND EYE
A REQUIREMENT FOR BONE MORPHOGENETIC PROTEIN-7 DURING DEVELOPMENT OF THE MAMMALIAN KIDNEY AND EYE
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DOI：
10.1101/gad.9.22.2795
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发表时间：
1995-11-15
影响因子：
10.5
通讯作者：
ROBERTSON, EJ
中科院分区：
文献类型：
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作者：
DUDLEY, AT;LYONS, KM;ROBERTSON, EJ
BMP-7/OP-1是分泌生长因子的转化生长因子-β（TGF-β）家族的成员，在小鼠胚胎发生期间以一种模式表达，表明在各种诱导组织相互作用中的潜在作用。目前的研究表明，缺乏BMP-7的小鼠表现出严重的缺陷，仅限于发育中的肾脏和眼睛。令人惊讶的是，负责建立这两个器官的早期诱导组织相互作用似乎基本上不受影响。然而，BMP-7的缺乏破坏了其持续生长和发育所需的后续细胞相互作用。因此，纯合子突变动物在出生时表现出肾发育不良和无眼症。总之，这些发现确定BMP-7作为哺乳动物肾脏和眼睛发育过程中的重要信号分子。
BMP-7/OP-1, a member of the transforming growth factor-beta (TGF-beta) family of secreted growth factors, is expressed during mouse embryogenesis in a pattern suggesting potential roles in a variety of inductive tissue interactions. The present study demonstrates that mice lacking BMP-7 display severe defects confined to the developing kidney and eye. Surprisingly, the early inductive tissue interactions responsible for establishing both organs appear largely unaffected. However, the absence of BMP-7 disrupts the subsequent cellular interactions required for their continued growth and development. Consequently, homozygous mutant animals exhibit renal dysplasia and anophthalmia at birth. Overall, these findings identify BMP-7 as an essential signaling molecule during mammalian kidney and eye development.