Compressed sensing of spatial electron paramagnetic resonance imaging.

Compressed sensing of spatial electron paramagnetic resonance imaging.
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DOI:
10.1002/mrm.24966
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发表时间:
2014-09
影响因子:
3.3
通讯作者:
Zweier, Jay L.
Zweier, Jay L.
中科院分区:
医学3区
文献类型:
--
作者:
Johnson, David H.;Ahmad, Rizwan;He, Guanglong;Samouilov, Alexandre;Zweier, Jay L.

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To improve image quality and reduce data requirements for spatial electron paramagnetic resonance imaging (EPRI) by developing a novel reconstruction approach using compressed sensing (CS). EPRI is posed as an optimization problem, which is solved using regularized least-squares with sparsity promoting penalty terms, consisting of the ℓ1 norms of the image itself and the Total Variation of the image. Pseudo-random sampling was employed to facilitate recovery of the sparse signal. The reconstruction was compared to the traditional Filtered Back-Projection reconstruction for simulations, phantoms, isolated rat hearts, and mouse GI tracts labeled with paramagnetic probes. A combination of pseudo-random sampling and CS was able to generate high-fidelity EPR images at high acceleration rates. For 3D phantom imaging, CS-based EPRI showed little visual degradation at 9-fold acceleration. In rat heart datasets, CS-based EPRI produced high quality images with 8-fold acceleration. A high resolution mouse GI tract reconstruction demonstrated a visual improvement in spatial resolution and a doubling in SNR. A novel 3D EPRI reconstruction utilizing compressed sensing was developed and offers superior SNR and reduced artifacts from highly undersampled data.
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