Elevated plasma endothelin-1 and cytokine levels in children with severe acute respiratory distress syndrome
Elevated plasma endothelin-1 and cytokine levels in children with severe acute respiratory distress syndrome
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DOI：
10.1016/s0022-3476(99)70029-6
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发表时间：
1999-08-01
影响因子：
5.1
通讯作者：
Abman, SH
中科院分区：
文献类型：
--
作者：
Dobyns, EL;Eells, PL;Abman, SH
我们对23名患有严重急性呼吸窘迫综合征的儿童在发病的头7天内进行了血浆内皮素-1和细胞因子（白细胞介素-1、白细胞介素-6和肿瘤坏死因子- α）水平的连续测量。我们报道血浆内皮素-1和白细胞介素-6水平在急性呼吸窘迫综合征患者中升高，并且血浆内皮素-1水平在非幸存者的早期临床过程中明显高于幸存者。我们得出结论，血浆内皮素-1水平在严重急性呼吸窘迫综合征儿童中显着升高，并推测高水平可能作为预后不良的早期标志。
We performed serial measurements of plasma endothelin-1 and cytokine levels (interleukin-1, interleukin-6 and tumor necrosis factor-alpha) in 23 children with severe acute respiratory distress syndrome during their first 7 days of disease. We report plasma endothelin-1 and interleukin-6 levels are increased in patients with acute respiratory distress syndrome, and that plasma endothelin-1 levels are significantly greater early in the clinical course of nonsurvivors than survivors, We conclude that plasma endothelin-l levels are markedly increased in children with severe acute respiratory distress syndrome and speculate that high levels may serve as an early marker of poor outcome.