The effects of cimetidine on serum calcium and parathyroid hormone levels in primary hyperparathyroidism.
The effects of cimetidine on serum calcium and parathyroid hormone levels in primary hyperparathyroidism.
复制标题
西咪替丁对原发性甲状旁腺功能亢进症患者血清钙和甲状旁腺激素水平的影响。
DOI：
10.1111/j.1365-2125.1982.tb04960.x
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发表时间：
1982
影响因子：
3.4
通讯作者：
D. Heath
中科院分区：
文献类型：
--
作者：
R. Fisken;R. Wilkinson;D. Heath
1据报道，西咪替丁可降低原发性甲状旁腺功能亢进患者的血清钙和甲状旁腺激素（PTH）水平，但一些研究报告了阴性结果。[2]因此，进行了一项西咪替丁在这种情况下的双盲对照试验。8例患者随机接受西咪替丁和安慰剂治疗，各2个月。只有一个病人表现出显着下降，血清钙西咪替丁和没有病人表现出下降，甲状旁腺激素水平。3此外，8名患者在48小时连续静脉输注西咪替丁期间进行了研究。前五名患者显示药物对PTH水平的钙没有影响，但在第六名患者中，PTH似乎有剂量依赖性抑制。因此，第七和第八名患者给予更高剂量的药物，但未能抑制钙或PTH值。4西咪替丁对原发性甲状旁腺功能亢进无治疗价值。
1 Cimetidine has been reported to reduce serum calcium and parathyroid hormone (PTH) levels in primary hyperparathyroidism, but some studies have reported negative findings. 2 A double-blind, controlled trial of cimetidine in this condition was, therefore, conducted. Eight patients were given cimetidine and placebo for 2 months each, in random order. Only one patient showed a significant fall in serum calcium on cimetidine and no patient showed a fall in PTH levels. 3 In addition, eight patients were studied during a 48 h continuous intravenous infusion of cimetidine. The first five patients exhibited no effect of the drug on either calcium of PTH levels, but in the sixth there appeared to be a dose-dependent suppression of PTH. The seventh and eighth patients were, therefore, given a higher dose of the drug but it failed to suppress calcium or PTH values. 4 It is concluded that cimetidine is not of value in primary hyperparathyroidism.