Recent Advances in Nanotherapeutics for Neurological Disorders.
Recent Advances in Nanotherapeutics for Neurological Disorders.
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DOI：
10.1021/acsabm.3c00254
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发表时间：
2023-07-17
影响因子：
4.7
通讯作者：
Nair, Madhavan
中科院分区：
文献类型：
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作者：
Vashist, Arti;Manickam, Pandiaraj;Raymond, Andrea D;Arias, Adriana Yndart;Kolishetti, Nagesh;Vashist, Atul;Arias, Emanuel;Nair, Madhavan
神经系统疾病仍然是世界范围内的重大健康和经济负担。解决现有药物、相关副作用和神经退行性疾病中的免疫反应所带来的挑战对于开发更好的疗法至关重要。疾病状态下的免疫激活具有复杂的治疗方案，并导致临床转化的障碍。存在对开发具有各种性质的多功能纳米治疗剂的巨大需求，以解决现有治疗剂所表现出的不同限制和免疫相互作用。纳米技术已经证明了其改善治疗传递和提高疗效的潜力。在开发可以与CRISPR/Cas9或siRNA结合的纳米疗法方面已经取得了有希望的进展，这些纳米疗法具有独特的临床转化潜力。工程化源自间充质干细胞（MSC）、树突细胞（DC）或巨噬细胞的天然外泌体以递送治疗剂并调节对肿瘤或神经退行性疾病（ND）的免疫应答可以允许靶向个性化治疗方法。在本综述中，我们总结和概述了纳米治疗药物在解决现有治疗限制和神经免疫相互作用方面的最新进展，以开发ND疗法，并为即将到来的基于纳米技术的纳米载体的进展提供见解。
Neurological disorders remain a significant health and economic burden worldwide. Addressing the challenges imposed by existing drugs, associated side- effects, and immune responses in neurodegenerative diseases is essential for developing better therapies. The immune activation in a diseased state has complex treatment protocols and results in hurdles for clinical translation. There is an immense need for the development of multifunctional nanotherapeutics with various properties to address the different limitations and immune interactions exhibited by the existing therapeutics. Nanotechnology has proven its potential to improve therapeutic delivery and enhance efficacy. Promising advancements have been made in developing nanotherapies that can be combined with CRISPR/Cas9 or siRNA for a targeted approach with unique potential for clinical translation. Engineering natural exosomes derived from mesenchymal stem cells (MSCs), dendritic cells (DCs), or macrophages to both deliver therapeutics and modulate the immune responses to tumors or in neurodegenerative disease (ND) can allow for targeted personalized therapeutic approaches. In the present review, we summarize and overview the recent advances in nanotherapeutics in addressing the existing treatment limitations and neuroimmune interactions for developing ND therapies and provide insights into the upcoming advancements in nanotechnology-based nanocarriers.