Standardized tests of heart rate variability: normal ranges obtained from 309 healthy humans, and effects of age, gender, and heart rate
Standardized tests of heart rate variability: normal ranges obtained from 309 healthy humans, and effects of age, gender, and heart rate
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DOI：
10.1007/bf02322053
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发表时间：
2001-04-01
影响因子：
5.8
通讯作者：
Ziegler, D
中科院分区：
文献类型：
--
作者：
Agelink, MW;Malessa, R;Ziegler, D
作者进行了这项研究，以确定年龄，性别和心率（MR）对心脏自主功能测试结果的影响，以测量大样本健康受试者（n = 309）的心率变异性（HRV）。使用常规测试（深呼吸，最大/最小30：15比例）和标准化5分钟静息研究，包括HR频谱分析。主要发现包括：（1）除低频（LF）与高频（HF）频谱功率比外，所有测试的指标（2）5分钟频谱带（LF/HF比值）和HR本身与年龄呈负相关;（LF/HF比除外）、变异系数、深呼吸期间的呼气-吸气比以及最大/最小30：15比值与心率无关;（3）55岁以下女性静息心率高于男性;（4）中青年女性LF功率和LF/HF比值显著低于同龄男性，而HF绝对功率无显著性别差异。作者计算了这里研究的每个HRV指标的年龄和性别相关的正常值，并讨论了HRV性别差异所产生的临床后果。
The authors undertook this study to determine the effects of age, gender, and heart rate MR) on the results of cardiac autonomic function tests for measuring heart rate variability (HRV) in a large sample of healthy subjects (n = 309). Conventional tests (deep breathing, maximum/minimum 30:15 ratio), and a standardized 5-minute resting study, including spectral analysis of HR, were used. The main findings included (1) the indices of all tests, except for the ratio of the low- (LF) to high-frequency (HF) spectral power (LF/HF ratio) and HR itself, are inversely related to age in both sexes; (2) the 5-minute spectral bands (except for the LF/HF ratio), the variation coefficient, expiratory-inspiratory ratio during deep breathing, and the maximum/minimum 30:15 ratio are independent of HR; (3) women up to the age of 55 years have a higher resting HR compared with men; (4) young and middle-aged women show a significantly lower LF power and LF/HF ratio compared with age-matched men, whereas no significant gender differences are observed in the absolute HF power. The authors computed age- and gender-dependent normal values for each of the HRV indices studied here and discuss the clinical consequences arising from gender differences in HRV.