Endogenous cortisol level interacts with noradrenergic activation in the human amygdala
Endogenous cortisol level interacts with noradrenergic activation in the human amygdala
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DOI：
10.1016/j.nlm.2006.05.008
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发表时间：
2007-01-01
影响因子：
2.7
通讯作者：
Rombouts, Serge A. R. B.
中科院分区：
文献类型：
--
作者：
van Stegeren, Anda H.;Wolf, Oliver T.;Rombouts, Serge A. R. B.
动物研究表明，高皮质醇水平通过调节杏仁核对压力任务的表现产生影响。该脑区去甲肾上腺素的可用性似乎是这种效果的关键先决条件。去甲肾上腺素和皮质醇之间的关系。这可以用一个动物模型来解释，其中杏仁核构成了这种相互作用的关键区域。到目前为止，这个模型还没有在人类身上进行过广泛的测试。在先前报道的一项研究中，人类受试者（年龄20.93 +/- 2.38岁）在服用p -肾上腺素能拮抗剂心得安或安慰剂后，在观看情绪和中性图片时使用功能磁共振成像进行扫描。刺激组由92张图片组成，分为四个情感类别，从中性的家庭物品场景（CAT1）到极端消极的残害或事故场景（CAT4）。面对唤起情绪的图片，伴随着去甲肾上腺素水平的增加，在安慰剂条件下引起杏仁核激活增加，而在β受体阻滞剂条件下则没有。这项新的和额外的数据集分析是为了确定不同内源性皮质醇水平对杏仁核激活的影响。扫描过程中使用唾液样本测定皮质醇水平，并将受试者临时分为高皮质醇组（n = 14）和低皮质醇组（n = 14）。当受试者观看情绪刺激时（可能与去甲肾上腺素（NA）水平升高有关），两个皮质醇组的杏仁核激活情况进行了对比。我们假设情绪刺激会引发更多的杏仁核，激活在高皮质醇组比在低皮质醇组。在这里，我们确实证明了内源性皮质醇水平与杏仁核激活增加之间的显著相互作用，而在安慰剂而不是β受体阻滞剂条件下，从而将两种应激激素协同作用的啮齿动物模型扩展到人类。(c) 2006爱思唯尔公司版权所有。
Animal studies show that high cortisol levels exert their effect on stressful task performance via modulation of the amygdala. Availability of noradrenaline in this brain region appears to be a critical prerequisite for this effect. This relationship between noradrenaline and cortisol. is explained by an animal model where the amygdala constitutes a crucial region for this interaction. In humans this model has not been extensively tested so far. In a previously reported study human subjects (aged 20.93 +/- 2.38) were scanned using fMRI when watching sets of emotional and neutral pictures after taking the P-adrenergic antagonist propranolol or placebo. Stimulus sets consisted of 92 pictures, divided in four emotional categories that ranged from neutral scenes of domestic objects (CAT1) to extremely negative scenes of mutilation or accidents (CAT4). Confrontation with arousing emotional pictures, accompanied by increased noradrenaline levels, evoked increased amygdala activation under placebo but not under betablocker condition. This new and additional analysis of this data set was carried out to determine the effect of differential endogenous cortisol levels on amygdala activation. Cortisol levels during scanning were determined using salivary samples and subjects were post hoc divided in a High (n = 14) and Low cortisol group (n = 14). When subjects were watching emotional stimuli, presumably associated with enhanced noradrenaline (NA) levels, amygdala activation was contrasted between the two cortisol groups. We hypothesized that emotional stimuli would elicit more amygdala, activation in the High than in the Low cortisol group. Here we demonstrate indeed a significant interaction effect of the endogenous cortisol level with increasing activation in the amygdala under placebo but not under betablocker condition, thereby extending the rodent based model of a synergistic effect of the two stress hormones to the human. (c) 2006 Elsevier Inc. All rights reserved.