Regulation of hematopoietic stem cell aging by the small RhoGTPase Cdc42.
Regulation of hematopoietic stem cell aging by the small RhoGTPase Cdc42.
复制标题
小 RhoGTPase Cdc42 对造血干细胞衰老的调节。
DOI：
10.1016/j.yexcr.2014.09.001
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发表时间：
2014
影响因子：
3.7
通讯作者：
Zheng,Yi
中科院分区：
文献类型：
--
作者：
Geiger,Hartmut;Zheng,Yi
干细胞的老化可能是组织老化的根本原因，在成年人中，组织严重依赖干细胞活性，如血液形成系统。造血，即造血细胞的产生，由造血干细胞维持。在这篇综述文章中，我们介绍了与老年HSC相关的典型表型集，专注于新的衰老相关的表型apolarity所造成的小RhoGTs活性升高老年HSC，讨论Cdc42在造血中的作用，并描述了药物抑制Cdc42活性在老年HSC的结果在功能上年轻，从而振兴HSC。
Aging of stem cells might be the underlying cause of tissue aging in tissue that in the adult heavily rely on stem cell activity, like the blood forming system. Hematopoiesis, the generation of blood forming cells, is sustained by hematopoietic stem cells. In this review article, we introduce the canonical set of phenotypes associated with aged HSCs, focus on the novel aging-associated phenotype apolarity caused by elevated activity of the small RhoGTPase in aged HSCs, discuss the role of Cdc42 in hematopoiesis and describe that pharmacological inhibition of Cdc42 activity in aged HSCs results in functionally young and thus rejuvenated HSCs.