Microscopic polyangiitis associated with primary biliary cirrhosis: a causal or casual association?
Microscopic polyangiitis associated with primary biliary cirrhosis: a causal or casual association?
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与原发性胆汁性肝硬化相关的显微镜下多血管炎：因果关系还是偶然关系？
作者：
L. Amezcua;P. Prieto;R. Bojalil;C. Pineda;M. Amigo
显微镜下多血管炎（MPA）和原发性胆汁性肝硬化（PBC）之间的关系很少报道。我们描述了一个PBC和MPA的病人，他表现为多关节炎和肺结节，随后是免疫缺陷新月体肾炎和肝功能障碍。p-ANCA、抗髓过氧化物酶和抗线粒体抗体的检测沿着肝和肾组织病理学检查允许MPA和PBC的诊断。我们还讨论了其他2例可能是未被认识到的协会这两种疾病。有必要进一步报告，以澄清PBC和MPA之间的共存是因果关系还是偶然的。
The association between microscopic polyangiitis (MPA) and primary biliary cirrhosis (PBC) has seldom been reported. We describe a patient with PBC and MPA who presented with polyarthritis and pulmonary nodules followed by pauci-immune crescentic glomerulonephritis and liver dysfunction. Detection of p-ANCA, antimyeloperoxidase, and antimitochondrial antibodies along with liver and renal histopathology allowed a diagnosis of MPA and PBC. We also discuss 2 other cases that could be unrecognized associations of both diseases. Further reports are necessary to clarify if the coexistence between PBC and MPA is causal or casual.