Continuous Blood Viscosity Monitoring System for Cardiopulmonary Bypass Applications
Continuous Blood Viscosity Monitoring System for Cardiopulmonary Bypass Applications
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DOI：
10.1109/tbme.2016.2610968
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发表时间：
2017-07-01
影响因子：
4.6
通讯作者：
Tsuji, Toshio
中科院分区：
文献类型：
--
作者：
Okahara, Shigeyuki;Soh, Zu;Tsuji, Toshio
本文提出了一种估计体外循环(CPB)期间血液粘度的算法，并在临床病例中进行了验证。所提出的算法包括基于氧合器和流体类型的可调参数，并基于通过氧合器的流体的压力-流量特性来估计血液粘度。这个新的非线性模型需要四个参数，这些参数是通过体外实验得出的。然后将该方法估计的结果与传统的线性模型进行了比较，证明了前者的最优曲线拟合。对20例接受轻度低温体外循环的患者进行了粘度(Eta(E))与粘度计测量的粘度(Eta(E))的比较。将研制的系统应用于10例患者，记录ETA(E)以与红细胞压积和血温进行比较。两个曲线拟合的残差平方和证实了显著差异，p<；为0.001。Eta(E)和。与R-2=0.9537和p<；0.001有很强的相关性。对于所有病例的平均决定系数，红细胞压积和温度分别在0.33+/-0.14和0.22+/-0.21之间显示出弱相关性。在所有病例的CPB测量中，ETA(E)超过98%分布在1~3mPa.s的范围内。这一新的粘度估算系统可用于检测CPB期间可能发生的各种粘度相关效应。
This paper proposes an algorithm that estimates blood viscosity during cardiopulmonary bypass (CPB) and validates its application in clinical cases. The proposed algorithm involves adjustable parameters based on the oxygenator and fluid types and estimates blood viscosity based on pressure-flow characteristics of the fluid perfusing through the oxygenator. This novel nonlinear model requires four parameters that were derived by in vitro experiments. The results estimated by the proposed method were then compared with a conventional linear model to demonstrate the former's optimal curve fitting. The viscosity (eta(e)) estimated using the proposed algorithm and the viscosity (eta) measured using a viscometer were compared for 20 patients who underwent mildly hypothermic CPB. The developed system was applied to ten patients, and eta(e) was recorded for comparisons with hematocrit and blood temperature. The residual sum of squares between the two curve fittings confirmed the significant difference, with p < 0.001. eta(e) and. showed a very strong correlation with R-2 = 0.9537 and p < 0.001. Regarding the mean coefficient of determination for all cases, the hematocrit and temperature showed weak correlations at 0.33 +/- 0.14 and 0.22 +/- 0.21, respectively. For CPB measurements of all cases, eta(e) was more than 98% distributed in the range from 1 to 3 mPa.s. This new system for estimating viscosity may be useful for detecting various viscosity-related effects that may occur during CPB.