Iridium-Catalyzed Enantioselective Intramolecular Hydroarylation of Allylic Aryl Ethers Devoid of a Directing Group on the Aryl Group
Iridium-Catalyzed Enantioselective Intramolecular Hydroarylation of Allylic Aryl Ethers Devoid of a Directing Group on the Aryl Group
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铱催化芳基上不含导向基团的烯丙基芳基醚的对映选择性分子内加氢芳基化
DOI：
10.1039/d1cc05684k
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
M.
中科院分区：
文献类型：
--
作者：
Ohmura. T.; Kusaka;S.; Suginome;M.
虽然分子内氢芳基化是烯丙基芳基醚的一种诱人的转化，但它的底物范围很窄。本文描述了Ir/(S)-DTBM-SEGPHOS催化的烯丙基芳醚分子内氢芳化反应。该反应消除了芳基的结构要求，提供了2，3-二氢苯并呋喃，在C3位置具有立体碳中心，对映体过剩高达99%。
Although intramolecular hydroarylation is an attractive transformation of allylic aryl ethers, it has suffered from narrow substrate scope. We herein describe Ir/(S)-DTBM-SEGPHOS-catalyzed intramolecular hydroarylation of allylic aryl ethers. The reaction eliminates the structural requirement from the aryl group, affording 2,3-dihydrobenzofurans bearing a stereogenic carbon center at the C3 position with up to 99% enantiomeric excess.