Complex genotype interactions influence social fitness during the developmental phase of the social amoeba Dictyostelium discoideum
Complex genotype interactions influence social fitness during the developmental phase of the social amoeba Dictyostelium discoideum
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DOI：
10.1111/j.1420-9101.2010.02032.x
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发表时间：
2010-08-01
影响因子：
2.1
通讯作者：
Wolf, J. B.
中科院分区：
文献类型：
--
作者：
Buttery, N. J.;Thompson, C. R. L.;Wolf, J. B.
当个体相互作用时，表型变异可以分为个体自身基因型的直接遗传效应（DGE）、其社会伙伴基因型的间接遗传效应（IGE）和相互作用个体的基因型之间的上位性相互作用（“基因型-基因型（GxG）上位性”）。这些组成部分都可以在进化过程中发挥重要作用，但很少有实证研究探讨了它们的重要性。社会阿米巴Dictyosteelium discoideum提供了一个理想的系统来衡量这些影响在社会互动和发展。当饥饿时，自由生活的变形虫聚集并分化成一个多细胞子实体，具有一个死茎，可以保持存活的孢子。通过测量一组天然菌株之间的相互作用，我们量化DGE，IGES和GxG上位性影响孢子形成。我们发现，DGE解释了大部分的表型方差（57.6%），而IGES解释了一个较小的（13.3%），但非常显着的组件。有趣的是，GxG上位性解释了近四分之一的方差（23.0%），突出了基因型相互作用的复杂性。这些结果表明，社会互动可以对发展产生很大的影响，并建议社会效应应发挥重要作用，在这个系统中的发展演变。
When individuals interact, phenotypic variation can be partitioned into direct genetic effects (DGEs) of the individuals' own genotypes, indirect genetic effects (IGEs) of their social partners' genotypes and epistatic interactions between the genotypes of interacting individuals ('genotype-by-genotype (GxG) epistasis'). These components can all play important roles in evolutionary processes, but few empirical studies have examined their importance. The social amoeba Dictyostelium discoideum provides an ideal system to measure these effects during social interactions and development. When starved, free-living amoebae aggregate and differentiate into a multicellular fruiting body with a dead stalk that holds aloft viable spores. By measuring interactions among a set of natural strains, we quantify DGEs, IGEs and GxG epistasis affecting spore formation. We find that DGEs explain most of the phenotypic variance (57.6%) whereas IGEs explain a smaller (13.3%) but highly significant component. Interestingly, GxG epistasis explains nearly a quarter of the variance (23.0%), highlighting the complex nature of genotype interactions. These results demonstrate the large impact that social interactions can have on development and suggest that social effects should play an important role in developmental evolution in this system.