Chronic systemic delivery of insulin through the ocular route.
Chronic systemic delivery of insulin through the ocular route.
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通过眼部途径慢性全身输送胰岛素。
DOI：
10.1089/jop.1993.9.85
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Li,BH
中科院分区：
文献类型：
--
作者：
Chiou,GC;Li,BH
将0.25%胰岛素加0.5%BL-9或Brij-78滴眼液滴入兔眼，每日2次，连续3个月。发现胰岛素降低血糖浓度的功效和体循环中胰岛素的摄取在整个实验期间保持相同。未检测到过敏反应或局部副作用，表明胰岛素和渗透促进剂（BL-9和Brij-78）均可安全地长期滴入眼睛。结论：长期给予胰岛素和吸收促进剂是一种可行的方法，以取代注射治疗糖尿病。
Eyedrops of 0.25% insulin plus 0.5% BL-9 or Brij-78 were instilled into rabbit eyes twice a day for 3 months. It was found that the efficacy of insulin to lower the blood glucose concentration and the uptake of insulin into the systemic circulation remained the same throughout the experimental period. No allergic responses or local side effects could be detected, indicating that both insulin and permeation enhancers (BL-9 and Brij-78) are safe for instillation into the eyes for long periods of time. It is concluded that chronic administration of insulin and absorption enhancers into the eyes is a feasible method to replace injections for diabetes treatment.
影响因子：
16.2
作者：
G. Chiou;C. Chuang;M. Chang
通讯作者：
M. Chang
通过眼部途径全身递送多肽药物。
DOI：
10.1146/annurev.pa.31.040191.002325
发表时间：
1991
影响因子：
12.5
作者：
Chiou,GC
通讯作者：
Chiou,GC