The incidence of hepatocellular carcinoma associated with hepatitis C infection decreased in Kyushu area.
The incidence of hepatocellular carcinoma associated with hepatitis C infection decreased in Kyushu area.
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DOI：
10.12659/msm.881375
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发表时间：
2011-02
期刊：
影响因子：
--
通讯作者：
Sata M
中科院分区：
文献类型：
--
作者：
Taura N;Fukushima N;Yastuhashi H;Takami Y;Seike M;Watanabe H;Mizuta T;Sasaki Y;Nagata K;Tabara A;Komorizono Y;Taketomi A;Matsumoto S;Tamai T;Muro T;Nakao K;Fukuizumi K;Maeshiro T;Inoue O;Sata M
日本肝细胞癌（HCC）的发病率仍在增加。本研究的目的是分析日本九州西部地区肝癌的流行病学趋势。本研究共招募了1996年至2008年期间在九州肝癌研究组（LCSK）诊断的10，010例HCC患者。HCC患者队列被分为5年间隔。HCC的病因可分为以下四组：B组：HBsAg阳性，HCV-RNA阴性; C组：HCV-RNA阳性，HBsAg阴性; B+C组：HBsAg和HCV-RNA均阳性; B为14.8%（10,010例中的1,485例），而68.1%（10,010例中的6,819例）为C，1.4%（10,010例中的140例）患有与两种病毒相关的HCC。其余1,566例患者（15.6%）与两种病毒均无关。HCC患者队列被分为6年间隔（1996-2001年和2002-2007年）。C类病例的比例从1996-2001年的73.1%下降到2002-2007年的64.9%。另一方面，B和非BC病例分别从1996-2001年的13.9%和11.3%显著增加到2002-2007年的16.2%和17.6%。2001年以后九州地区与丙型肝炎感染相关的肝细胞癌发病率下降。这种变化是由于HCC的数量和比例增加，不仅是非BC患者，而且还有B患者。
The incidence of hepatocellular carcinoma (HCC) in Japan has still been increasing. The aim of the present study was to analyze the epidemiological trend of HCC in the western area of Japan, Kyushu. A total of 10,010 patients with HCC diagnosed between 1996 and 2008 in the Liver Cancer study group of Kyushu (LCSK), were recruited for this study. Cohorts of patients with HCC were categorized into five year intervals. The etiology of HCC was categorized to four groups as follows; B: HBsAg positive, HCV-RNA negative, C: HCV-RNA positive, HBsAg negative, B+C: both of HBsAg and HCV-RNA positive, nonBC: both of HBsAg and HCV-RNA negative. B was 14.8% (1,485 of 10,010), whereas 68.1% (6,819 of 10,010) had C, and 1.4% (140 of 10,010) had HCC associated with both viruses. The remaining 1,566 patients (15.6%) did not associate with both viruses. Cohorts of patients with HCC were divided into six-year intervals (1996–2001 and 2002–2007). The ratio of C cases decreased from 73.1% in 1996–2001 to 64.9% in 2002–2007. On the other hand, B and -nonBC cases increased significantly from 13.9% and 11.3% in 1996–2001 to 16.2% and 17.6% in 2002–2007, respectively. The incidence of hepatocellular carcinoma associated with hepatitis C infection decreased after 2001 in Kyushu area. This change was due to the increase in the number and proportion of the HCC not only nonBC patients but also B patients.
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影响因子：
25.7
作者：
Planas, R;Ballesté, B;Sola, R
通讯作者：
Sola, R
影响因子：
13.5
作者：
Lai, Mei-Shu;Hsieh, Meng-Shu;Chen, Tony Hsiu-Hsi
通讯作者：
Chen, Tony Hsiu-Hsi
影响因子：
29.4
作者：
Davila, JA;Morgan, RO;El-Serag, HB
通讯作者：
El-Serag, HB
影响因子：
12.6
作者：
Muto, Y;Sato, S;Kumada, H
通讯作者：
Kumada, H
影响因子：
3.5
作者：
Kiyosawa, K;Tanaka, E
通讯作者：
Tanaka, E