Prognostic value of biventricular mechanical parameters assessed using cardiac magnetic resonance feature-tracking analysis to predict future cardiac events
Prognostic value of biventricular mechanical parameters assessed using cardiac magnetic resonance feature-tracking analysis to predict future cardiac events
复制标题
使用心脏磁共振特征跟踪分析评估双心室机械参数的预后价值，以预测未来的心脏事件
DOI：
10.1002/jmri.25433
复制
发表时间：
2017
影响因子：
4.4
通讯作者：
Takeuchi M
中科院分区：
文献类型：
--
作者：
Yang L-T;Yamashita E;Nagata Y;Kado Y;Oshima S;Otsuji Y;Takeuchi M
PurposeTo研究和比较心脏磁共振特征跟踪（MR-FT）的双心室应变parameters.Materials和MethodsWe回顾性纳入364例患者进行临床指征心脏MR检查（1.5或3 T扫描仪）的预后价值。使用标准稳态自由进动（SSFP）图像进行分析。使用常规圆盘面积总和法测量左心室（LV）和右心室（RV）射血分数（EF）。使用MR-FT测量双心室应变参数。结果两种方法测定的左室容积与LVEF的相关性良好（r= 0.87-0.98）。RV毒株参数与RVEF中度相关（r= 0.44-0.63）。在中位随访15个月期间，36例患者发生了MACE。在单变量分析中，除右心室整体纵向应变外，所有MR-FT衍生参数均与未来MACE显著相关（P< 0.05）。在逐步考克斯比例风险模型中，在校正年龄、性别、常规LVEF（风险比0.93;P= 0.029）或RVEF（风险比0.93; P= 0.038）的模型中，RV整体径向应变（RVGRS）提供了增量预后价值。LV整体横向应变（LVGTS）也提供了年龄、性别、常规LVEF（风险比0.94;P= 0.041）或RVEF（风险比0.94;P= 0.004）的额外价值。Kaplan-Meier分析显示，采用MR-FT的LVGTS、RVGRS和LVEF的中位数分层的亚组中，生存率存在显著差异（所有对数秩P < 0.05）。结论采用MR-FT的双心室变形分析提供了与采用常规方法获得的参数相似的显著预后能力。MR‐FT是一种很有前途的替代方法，可用于心室腔定量和提供未来心脏事件的信息。证据等级：3 J。磁共振影像学2017;45：1034-1045
PurposeTo study and compare the prognostic value of cardiac magnetic resonance feature tracking (MR‐FT) of biventricular strain parameters with a conventional method.Materials and MethodsWe retrospectively enrolled 364 patients undergoing clinically indicated cardiac MR examinations (1.5 or 3T scanner). Standard steady‐state free precession (SSFP) images were used for analysis. Left ventricular (LV) and right ventricular (RV) ejection fraction (EF) were measured using conventional disk‐area summation methods. Biventricular strain parameters were measured using MR‐FT. All patients were followed to record major adverse cardiac events (MACEs).ResultsThe correlations between LV volumes and LVEF using both methods were excellent (r= 0.87–0.98). RV strain parameters were modestly correlated with RVEF (r= 0.44–0.63). During a median follow‐up of 15 months, 36 patients developed MACEs. All MR‐FT‐derived parameters except for RV global longitudinal strain were significantly associated with future MACEs (P< 0.05) in univariate analysis. In stepwise Cox proportional hazard models, RV global radial strain (RVGRS) provided incremental prognostic value in models adjusted for age, gender, conventional LVEF (hazard ratio 0.93;P= 0.029) or RVEF (hazard ratio 0.93;P= 0.038). LV global transverse strain (LVGTS) also offered additional value over age, gender, conventional LVEF (hazard ratio 0.94;P= 0.041), or RVEF (hazard ratio 0.94;P= 0.004). Kaplan–Meier analysis showed significant survival differences in subgroups stratified by the median value of LVGTS, RVGRS, and LVEF using MR‐FT (all log‐rankP< 0.05).ConclusionDeformation analysis of both ventricles using MR‐FT provided significant prognostic power similar to parameters obtained using conventional methods. MR‐FT is a promising alternative both for ventricular chamber quantification and for providing information of future cardiac events.Level of Evidence:3J. Magn. Reson. Imaging 2017;45:1034–1045