Phototoxic polyacetylenes and their thiophene derivatives [Effects on human skin]
Phototoxic polyacetylenes and their thiophene derivatives [Effects on human skin]
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光毒性聚乙炔及其噻吩衍生物[对人体皮肤的影响]
作者：
G. Towers;T. Árnason;C. Wat;E. Graham;J. Lam;J. Mitchell
测试了聚乙炔及其噻吩衍生物对人体皮肤的影响。外用α-terthienyl可引起双相光毒性皮炎，并在人的表皮出现“晒伤”细胞。11种聚乙炔虽然在对白色念珠菌和某些病原微生物的光毒作用中模仿了α-三硫烯基，但没有一种具有相同的作用。这些化合物的紫外线介导的抗生素活性和它们对皮肤的明显光毒性表明，它们在酵母菌、真菌和细菌感染以及光敏感型皮肤病中具有潜在的局部治疗作用。然而，它们的局部敏化能力尚未被研究。
Polyacetylenes and their thiophene derivatives were tested for their effects on human skin. Topically applied α‐terthienyl evoked bi‐phasic phototoxic dermatitis and the appearance of ‘sunburn’ cells in human epidermis. None of 11 polyacetylenes had the same effect although they mimicked α‐terthienyl in their phototoxic effects on Candida albicans and certain pathogenic microorganisms. The UV‐mediated antibiotic activity of the compounds and their apparent lack of phototoxicity towards the skin suggest a potential topical therapeutic role for them in yeast, fungal and bacterial infections and light‐responsive dermatoses. Their topical sensitizing capacity, however, has not yet been studied.