Early visual, processing deficits in schizophrenia: impaired PI generation revealed by high-density electrical mapping
Early visual, processing deficits in schizophrenia: impaired PI generation revealed by high-density electrical mapping
复制标题
DOI：
10.1097/00001756-200112040-00043
复制
发表时间：
2001-12-04
期刊：
影响因子：
1.7
通讯作者：
Javitt, DC
中科院分区：
文献类型：
--
作者：
Foxe, JJ;Doniger, GM;Javitt, DC
精神分裂症的早期视觉感觉处理的完整性进行了评估，以及表征PI和NI组成部分的视觉诱发电位（VEP）作为我们的依赖措施。VEP记录在响应连续较少碎片的线条画的共同对象。与对照组相比，患者在所有刺激条件下的PI振幅均显著降低。此外，这种递减在顶枕比枕颞电极部位相对更大。NI振幅无差异，发现PI赤字的患者，特别是在背侧头皮，支持这样的观点，即精神分裂症与早期背侧视觉流处理的损害。另一方面，在患者中发现正常NI振幅表明腹侧流处理的早期阶段可能相对更完整。这些结果意味着，精神分裂症患者的认知障碍不仅是由于认知的高阶方面的缺陷，而且还包括早期感觉处理的显着缺陷。NeuroReport 12：3815-3820（C）2001 Lippincott威廉姆斯和威尔金斯。
Integrity of early visual sensory processing in schizophrenia was assessed using the well characterized PI and NI components of the visual evoked potential (VEP) as our dependent measures. VEPs were recorded in response to successively less fragmented line drawings of common objects. PI amplitudes were significantly reduced across all stimulus conditions for patients versus controls. Further, this decrement was relatively greater at parieto-occipital than occipito-temporal electrode sites. No differences in NI amplitude were found. The finding of PI deficits in patients, particularly over dorsal scalp, supports the view that schizophrenia is associated with impairment of early dorsal visual stream processing. On the other hand, the finding of normal NI amplitudes in patients suggests that early stages of ventral stream processing may be relatively more intact. These results imply that the cognitive impairment seen in schizophrenia is not just due to deficits in higher order aspects of cognition but also encompasses significant deficits in early sensory processing. NeuroReport 12:3815-3820 (C) 2001 Lippincott Williams & Wilkins.