A StAR search: Implications in controlling steroidogenesis
A StAR search: Implications in controlling steroidogenesis
复制标题
DOI：
10.1095/biolreprod56.2.328
复制
发表时间：
1997-02-01
影响因子：
3.6
通讯作者：
Stocco, DM
中科院分区：
文献类型：
--
作者：
Stocco, DM
响应于营养激素的急性类固醇激素合成在胆固醇递送到线粒体内膜的水平上被控制，线粒体内膜是P450侧链裂解（P450（SCC））酶的位点，其将胆固醇转化为合成的第一种类固醇--双烯醇酮。已知该过程对从头蛋白质合成具有绝对要求。迄今为止，已经提出了几种蛋白质作为急性调节剂。这篇评论讨论了这样一个候选蛋白，类固醇生成急性调节（星星）蛋白，在这种调节中发挥的作用。
Acute steroid hormone synthesis in response to trophic hormone is controlled at the level of cholesterol delivery to the inner mitochondrial membrane, the site of the P450 side-chain cleavage (P450(scc)) enzyme that will convert it to pregnenolone, the first steroid synthesized, This process is known to have an absolute requirement for de novo protein synthesis. To date several proteins have been proposed as the acute regulator. This review discusses the role that one such candidate protein, the Steroidogenic Acute Regulatory (StAR) protein, plays in this regulation.